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Products:Neuroscience >> Neurology process >> Neurogenesis
Overview
Product name
Anti-HGFA Inhibitor 2 antibody - Cytoplasmic domain
See all HGFA Inhibitor 2 products (5) ...
Description
Rabbit polyclonal to HGFA Inhibitor 2 - Cytoplasmic domain
Specificity
This antibody is specific for HGFA Inhibitor 2. It will not recognize HGFA Inhibitor 1 and HAI-2 RSP (related small protein).
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide of Human HGFA Inhibitor 2. (Peptide available as ab41273.)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
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Western blot - HGFA Inhibitor 2 antibody - Cytoplasmic domain (ab28336)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab28336 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/5000.Detects a band of approximately 22 kDa (predicted molecular weight: 28 kDa).
Target
Function
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Tissue specificity
Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
Involvement in disease
Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3) [MIM:270420]; also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes.
Sequence similarities
Contains 2 BPTI/Kunitz inhibitor domains.
Domain
This inhibitor contains two inhibitory domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionO43291
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AL024025 antibody
- Bikunin, placental antibody
- C76321 antibody
see all
Database links
- Entrez Gene: 10653 Human
- Omim: 605124 Human
- SwissProt: O43291 Human
- Unigene: 31439 Human
Anti-HGFA Inhibitor 2 antibody - Cytoplasmic domain images:
Western blot - HGFA Inhibitor 2 antibody - Cytoplasmic domain (ab28336)
All lanes : Anti-HGFA Inhibitor 2 antibody - Cytoplasmic domain (ab28336) at 1/1000 dilution
Lane 1 : HGFA Inhibitor 2 (Cytoplasmic domain) at 0.05 µg
Lane 2 : HGFA Inhibitor 2 (Cytoplasmic domain) at 0.01 µg
Lane 3 : HGFA Inhibitor 2 (Cytoplasmic domain) at 0.001 µg
Predicted band size : 28 kDa
Observed band size : 23.5,32 kDa (why is the actual band size different from the predicted?)
Additional bands at : 56 kDa (possible dimer).
The HAI proteins are glycosylated, and may have other post-translational modifications, thus the apparent molecular weight is 22-32 Kda kDa for the full-length HAI-2
Protocols
References for Anti-HGFA Inhibitor 2 antibody - Cytoplasmic domain (ab28336)
ab28336 has not yet been referenced specifically in any publications.
Publishing research using ab28336? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"