• Product nameAnti-hHR23b antibody
    See all hHR23b primary antibodies
  • Description
    Rabbit polyclonal to hHR23b
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 10-40 of Human hHR23b (NP_002865.1).

  • Positive control
    • A549 cell line lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab123790 was purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products


Our Abpromise guarantee covers the use of ab123790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.


  • FunctionMultiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmatic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
    Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.
    The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
  • Sequence similaritiesBelongs to the RAD23 family.
    Contains 1 STI1 domain.
    Contains 2 UBA domains.
    Contains 1 ubiquitin-like domain.
  • DomainThe ubiquitin-like domain mediates interaction with ATXN3.
  • Cellular localizationNucleus. Cytoplasm. The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.
  • Information by UniProt
  • Database links
  • Alternative names
    • hHR 23b antibody
    • hHR23B antibody
    • HR 23B antibody
    • HR23B antibody
    • mHR 23B antibody
    • mHR23B antibody
    • p58 antibody
    • RAD 23B antibody
    • RAD23 (S. cerevisiae) homolog B antibody
    • RAD23 homolog B (S. cerevisiae) antibody
    • RAD23 homolog B antibody
    • RAD23 yeast homolog of B antibody
    • Rad23b antibody
    • RD23B_HUMAN antibody
    • UV excision repair protein RAD23 homolog B antibody
    • XP C repair complementing complex 58 kDa antibody
    • XP C repair complementing complex 58 kDa protein antibody
    • XP C repair complementing protein antibody
    • XP-C repair-complementing complex 58 kDa protein antibody
    • XPC repair complementing complex 58 kDa antibody
    • XPC repair complementing complex 58 kDa protein antibody
    • XPC repair complementing protein antibody
    see all

Anti-hHR23b antibody images

  • Anti-hHR23b antibody (ab123790) at 1/100 dilution + A549 cell line lysate at 35 µg

    Predicted band size : 43 kDa

References for Anti-hHR23b antibody (ab123790)

ab123790 has not yet been referenced specifically in any publications.

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