• Product nameAnti-HIC5 antibody [4B2-D8]
    See all HIC5 primary antibodies
  • Description
    Mouse monoclonal [4B2-D8] to HIC5
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-445 of Human HIC5



Our Abpromise guarantee covers the use of ab57754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
    • Tissue specificityExpressed in platelets, smooth muscle and prostate stromal cells (at protein level).
    • Sequence similaritiesBelongs to the paxillin family.
      Contains 4 LIM zinc-binding domains.
    • DomainThe LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
      The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
    • Post-translational
      Phosphorylated by gonadotropin-releasing hormone-activated SRC.
    • Cellular localizationCell junction > focal adhesion. Nucleus matrix. Cytoplasm > cytoskeleton. Associated with the actin cytoskeleton; colocalizes with stress fibers.
    • Information by UniProt
    • Database links
    • Alternative names
      • Androgen receptor coactivator 55 kDa protein antibody
      • Androgen receptor coactivator ARA55 antibody
      • Androgen receptor-associated protein of 55 kDa antibody
      • ARA55 antibody
      • Hic-5 antibody
      • Hydrogen peroxide-inducible clone 5 protein antibody
      • Tgfb1i1 antibody
      • TGFI1_HUMAN antibody
      • Transforming growth factor beta 1 induced transcript 1 antibody
      • Transforming growth factor beta-1-induced transcript 1 protein antibody
      • TSC 5 antibody
      see all

    Anti-HIC5 antibody [4B2-D8] images

    • Predicted band size : 48 kDa
      HIC5 antibody (ab57754) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-HIC5 antibody [4B2-D8] (ab57754)

    ab57754 has not yet been referenced specifically in any publications.

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