Anti-HIF-1 alpha antibody [EP1215Y] (ab51608)

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ab51608 has been referenced in 62 publications.

  • Zhao M  et al. Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia. Int J Mol Med 41:322-330 (2018). PubMed: 29138796
  • Liang H  et al. Hypoxia induces miR-153 through the IRE1a-XBP1 pathway to fine tune the HIF1a/VEGFA axis in breast cancer angiogenesis. Oncogene N/A:N/A (2018). PubMed: 29367761
  • Yang H  et al. An aptamer-Fe3+modified nanoparticle for lactate oxidation and tumor photodynamic therapy. Colloids Surf B Biointerfaces 164:192-200 (2018). PubMed: 29413596
  • Zou X  et al. Endogenous hormone 2-methoxyestradiol suppresses venous hypertension-induced angiogenesis through up- and down-regulating p53 and id-1. J Cell Mol Med 22:957-967 (2018). WB . PubMed: 29193609
  • Redlich N  et al. Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma. Cell Death Dis 9:5 (2018). WB . PubMed: 29305574
  • Dutta A  et al. Household air pollution and chronic hypoxia in the placenta of pregnant Nigerian women: A randomized controlled ethanol Cookstove intervention. Sci Total Environ 619-620:212-220 (2018). PubMed: 29149745
  • Liu M  et al. Effects and Mechanism of Huannao Yicong Decoction Extract on the Ethology of Transgenic APP/PS1 Mice. Evid Based Complement Alternat Med 2017:9502067 (2017). PubMed: 29422937
  • Ziólkowska-Suchanek I  et al. FAM13A as a Novel Hypoxia-Induced Gene in Non-Small Cell Lung Cancer. J Cancer 8:3933-3938 (2017). PubMed: 29187867
  • Liu J  et al. Parkin targets HIF-1a for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun 8:1823 (2017). PubMed: 29180628
  • Schive SW  et al. Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo. Cell Med 9:103-116 (2017). PubMed: 28713640
  • Shen P  et al. IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis. BMC Microbiol 17:185 (2017). PubMed: 28835201
  • Zhu L & Zhao Q Hypoxia-inducible factor 1a participates in hypoxia-induced epithelial-mesenchymal transition via response gene to complement 32. Exp Ther Med 14:1825-1831 (2017). PubMed: 28810656
  • Shao P  et al. MicroRNA-205-5p regulates the chemotherapeutic resistance of hepatocellular carcinoma cells by targeting PTEN/JNK/ANXA3 pathway. Am J Transl Res 9:4300-4307 (2017). PubMed: 28979703
  • Schaefer E  et al. Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization. Hepatol Commun 1:326-337 (2017). WB . PubMed: 29404462
  • Irtenkauf SM  et al. Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research. Comp Med 67:300-314 (2017). PubMed: 28830577
  • Sun N  et al. Inhibitory effect of dexamethasone on residual Lewis lung cancer cells in mice following palliative surgery. Oncol Lett 13:356-362 (2017). WB, IHC-P ; Mouse . PubMed: 28123567
  • Ponente M  et al. PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. JCI Insight 2:e87380 (2017). IHC-P ; Mouse . PubMed: 28239645
  • Zhao B  et al. Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-ß1/Smad3 pathway. Int J Mol Med 39:153-159 (2017). WB ; Human . PubMed: 27909731
  • Li Z  et al. Ferulic Acid Improves Functional Recovery after Acute Spinal Cord Injury in Rats by Inducing Hypoxia to Inhibit microRNA-590 and Elevate Vascular Endothelial Growth Factor Expressions. Front Mol Neurosci 10:183 (2017). WB ; Rat . PubMed: 28642684
  • Koziel A & Jarmuszkiewicz W Hypoxia and aerobic metabolism adaptations of human endothelial cells. Pflugers Arch 469:815-827 (2017). WB . PubMed: 28176017
  • Kumar S  et al. The role of tumour suppressor PDCD4 in beta cell death in hypoxia. PLoS One 12:e0181235 (2017). PubMed: 28750063
  • Zhao Y  et al. MicroRNA-33b inhibits cell proliferation and glycolysis by targeting hypoxia-inducible factor-1a in malignant melanoma. Exp Ther Med 14:1299-1306 (2017). PubMed: 28781622
  • Cosin-Roger J  et al. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat Commun 8:98 (2017). PubMed: 28740109
  • Zhou T  et al. Protective effect of sevoflurane on myocardial ischemia-reperfusion injury in rat hearts and its impact on HIF-1a and caspase-3 expression. Exp Ther Med 14:4307-4311 (2017). WB ; Rat . PubMed: 29104643
  • Zahoor M  et al. Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss. Blood Adv 1:2656-2666 (2017). PubMed: 29296919
  • Wang RX  et al. Melatonin downregulates nuclear receptor RZR/ROR? expression causing growth-inhibitory and anti-angiogenesis activity in human gastric cancer cells in vitro and in vivo. Oncol Lett 12:897-903 (2016). WB ; Mouse . PubMed: 27446366
  • Soncini M  et al. 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A 113:E6219-E6227 (2016). PubMed: 27671648
  • Humtsoe JO  et al. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene 35:1554-64 (2016). PubMed: 26073080
  • Liu YM  et al. Expression of HIF-1a and HIF-2a correlates to biological and clinical significance in papillary thyroid carcinoma. World J Surg Oncol 14:30 (2016). WB, IHC-P ; Human . PubMed: 26846782
  • Xu X  et al. Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo. Sci Rep 6:35771 (2016). Mouse . PubMed: 27767192
  • Wei X  et al. Long noncoding RNA ANRIL is activated by hypoxia-inducible factor-1a and promotes osteosarcoma cell invasion and suppresses cell apoptosis upon hypoxia. Cancer Cell Int 16:73 (2016). WB . PubMed: 27688736
  • Li L  et al. Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension. Sci Rep 6:37338 (2016). WB ; Rat . PubMed: 27869147
  • Li Y  et al. Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis. Front Immunol 7:532 (2016). WB ; Rat . PubMed: 28003810
  • Granados-Principal S  et al. Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer. Breast Cancer Res 17:25 (2015). PubMed: 25849745
  • Herwartz C  et al. The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells. Mediators Inflamm 2015:804264 (2015). WB ; Human . PubMed: 26229239
  • Qin W  et al. Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget 6:39839-54 (2015). WB, ICC/IF ; Human . PubMed: 26497999
  • Chen D  et al. MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1a-TWIST signaling axis in breast cancer. Oncotarget 6:32701-12 (2015). PubMed: 26196741
  • Wang TC  et al. Characterization of highly proliferative secondary tumor clusters along host blood vessels in malignant glioma. Mol Med Rep 12:6435-44 (2015). WB ; Rat . PubMed: 26299849
  • Chen T  et al. Factor inhibiting HIF1a (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1a pathway. Cancer Biol Ther 16:244-52 (2015). WB ; Human . PubMed: 25602156
  • Koh MY  et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res 75:316-29 (2015). PubMed: 25421578
  • Vanichapol T  et al. Hypoxia enhances cholangiocarcinoma invasion through activation of hepatocyte growth factor receptor and the extracellular signal-regulated kinase signaling pathway. Mol Med Rep 12:3265-72 (2015). IHC-P, ICC/IF ; Human . PubMed: 26018028
  • Ma B  et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol 17:95-103 (2015). PubMed: 25438054
  • Li J  et al. Inhibitory effects of B-cell lymphoma 2 on the vasculogenic mimicry of hypoxic human glioma cells. Exp Ther Med 9:977-981 (2015). WB ; Human . PubMed: 25667663
  • Shang A  et al. Upregulation of neuroglobin expression and changes in serum redox indices in a rat model of middle cerebral artery occlusion. Mol Med Rep 12:1693-8 (2015). WB ; Rat . PubMed: 25847303
  • Chan MC  et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One 10:e0132004 (2015). ELISA ; Human . PubMed: 26147748
  • Ng KP  et al. Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition. Blood 123:3316-26 (2014). ICC/IF . PubMed: 24705490
  • Zeindl-Eberhart E  et al. Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. PLoS One 9:e87386 (2014). IHC ; Human . PubMed: 24498091
  • Della Penna SL  et al. Renal overexpression of atrial natriuretic peptide and hypoxia inducible factor-1a as adaptive response to a high salt diet. Biomed Res Int 2014:936978 (2014). WB ; Rat . PubMed: 24689065
  • Chen L  et al. HIF-1 alpha overexpression correlates with poor overall survival and disease-free survival in gastric cancer patients post-gastrectomy. PLoS One 9:e90678 (2014). IHC-P ; Human . PubMed: 24614305
  • Xiao H  et al. BAG3 and HIF-1 a Coexpression Detected by Immunohistochemistry Correlated with Prognosis in Hepatocellular Carcinoma after Liver Transplantation. Biomed Res Int 2014:516518 (2014). WB, IHC-P ; Human . PubMed: 24895585
  • Cuffe JS  et al. Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner. J Physiol N/A:N/A (2014). PubMed: 24801305
  • Tsuzuki T  et al. Divergent regulation of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor by hypoxia and female sex steroids in human endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol N/A:N/A (2013). WB ; Human . PubMed: 23352606
  • Hsieh YL  et al. Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response. EMBO J 32:791-804 (2013). PubMed: 23395904
  • Deng B  et al. Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-ß1 in gastric cancer. PLoS One 8:e63777 (2013). ICC/IF ; Human . PubMed: 23723999
  • Wang Y  et al. Hypoxia-Inducible Factor-1alpha and MAPK Co-Regulate Activation of Hepatic Stellate Cells upon Hypoxia Stimulation. PLoS One 8:e74051 (2013). WB ; Human . PubMed: 24040163
  • Guan A  et al. Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis. PLoS One 8:e76529 (2013). WB ; Mouse . PubMed: 24098521
  • Laurinavicius A  et al. Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data. Diagn Pathol 7:27 (2012). IHC-P ; Human . PubMed: 22424533
  • Park MS  et al. Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. Anal Biochem 410:257-65 (2011). WB ; Human . PubMed: 21146485
  • Yuan LB  et al. Neuroprotective Effect of Orexin-A Is Mediated by an Increase of Hypoxia-inducible Factor-1 Activity in Rat. Anesthesiology 114:340-54 (2011). WB, IHC-P ; Rat . PubMed: 21239965
  • Szot CS  et al. 3D in vitro bioengineered tumors based on collagen I hydrogels. Biomaterials 32:7905-12 (2011). IHC . PubMed: 21782234
  • Ameri K  et al. Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype. Br J Cancer 102:561-9 (2010). IHC-P ; Human . PubMed: 20051957
  • Kim JO  et al. Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep 43:599-603 (2010). ICC/IF ; Human . PubMed: 20846491


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