Anti-HIF-1 alpha antibody [H1alpha67] - ChIP Grade (ab1)

Publishing research using ab1? Please let us know so that we can cite the reference in this datasheet.

ab1 has been referenced in 50 publications.

  • Sato M  et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep 12:3462-8 (2015). ICC/IF ; Human . PubMed: 26017562
  • Iwasaki K  et al. Role of hypoxia-inducible factor-1a, carbonic anhydrase-IX, glucose transporter-1 and vascular endothelial growth factor associated with lymph node metastasis and recurrence in patients with locally advanced cervical cancer. Oncol Lett 10:1970-1978 (2015). IHC-P ; Human . PubMed: 26622782
  • Kim BH  et al. Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization. Br J Pharmacol 172:3875-89 (2015). WB . PubMed: 25917462
  • Vavilala DT  et al. Evaluation of anti-HIF and anti-angiogenic properties of honokiol for the treatment of ocular neovascular diseases. PLoS One 9:e113717 (2014). WB, IF, ChIP ; Human . PubMed: 25422886
  • Ekman M  et al. HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Lab Invest 94:557-68 (2014). Rat . PubMed: 24589856
  • Auffinger B  et al. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy. Cell Death Differ 21:1119-31 (2014). Human . PubMed: 24608791
  • Moussa M  et al. Nanodrug-enhanced radiofrequency tumor ablation: effect of micellar or liposomal carrier on drug delivery and treatment efficacy. PLoS One 9:e102727 (2014). IHC-P ; Rat . PubMed: 25133740
  • Harrison H  et al. Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-a status. Cancer Res 73:1420-33 (2013). IHC ; Human . PubMed: 23248117
  • Tripathy D  et al. Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia. Front Aging Neurosci 5:19 (2013). IHC-P ; Mouse . PubMed: 23675346
  • Lan X  et al. High glucose enhances HIV entry into T cells through upregulation of CXCR4. J Leukoc Biol 94:769-77 (2013). Human . PubMed: 23911867
  • Velpula KK  et al. Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Cancer Res 73:7277-89 (2013). PubMed: 24148623
  • Carrière M  et al. HIV "Elite Controllers" Are Characterized by a High Frequency of Memory CD8+CD73+ T Cells Involved in the Antigen-Specific CD8+ T-cell Response. J Infect Dis N/A:N/A (2013). Human . PubMed: 24357632
  • Eckle T  et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18:774-82 (2012). WB . PubMed: 22504483
  • Elias I  et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 61:1801-13 (2012). WB ; Mouse . PubMed: 22522611
  • Bensellam M  et al. Glucose-induced O2 consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. PLoS One 7:e29807 (2012). WB . PubMed: 22235342
  • Paatero I  et al. Interaction with ErbB4 promotes hypoxia-inducible factor-1a signaling. J Biol Chem 287:9659-71 (2012). IHC-P ; Mouse . PubMed: 22308027
  • Ingraham CA  et al. Matrix Metalloproteinase (MMP)-9 Induced by Wnt Signaling Increases the Proliferation and Migration of Embryonic Neural Stem Cells at Low O2 Levels. J Biol Chem 286:17649-57 (2011). WB ; Rat . PubMed: 21460212
  • Bento CF  et al. Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction. Exp Physiol 95:955-70 (2010). WB, IHC-Fr ; Human, Rat . PubMed: 20562294
  • Pereira ER  et al. Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. PLoS One 5: (2010). WB ; Rat . PubMed: 20824063
  • Itoigawa Y  et al. Hypoxia induces adipogenic differentitation of myoblastic cell lines. Biochem Biophys Res Commun 399:721-6 (2010). WB ; Mouse . PubMed: 20692234
  • Viñas-Castells R  et al. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem 285:3794-805 (2010). WB ; Mouse, Human . PubMed: 19955572
  • Fisher CD  et al. Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos 37:2087-94 (2009). PubMed: 19651758
  • Bailey JM  et al. Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 28:3513-25 (2009). WB . PubMed: 19633682
  • Chiacchiera F  et al. p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. Cell Death Differ 16:1203-14 (2009). WB ; Human . PubMed: 19343039
  • Walczak-Drzewiecka A  et al. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J Immunol 181:1665-72 (2008). WB ; Human . PubMed: 18641302
  • Kane R  et al. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol Vis 14:1138-48 (2008). WB ; Human . PubMed: 18587495
  • Natarajan R  et al. Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium. Am J Physiol Heart Circ Physiol 293:H1571-80 (2007). PubMed: 17545479
  • Natarajan R  et al. Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury. Circ Res 98:133-40 (2006). PubMed: 16306444
  • Critchley HO  et al. Hypoxia-inducible factor-1alpha expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2). Endocrinology 147:744-53 (2006). PubMed: 16282352
  • Pisani DF  et al. SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers. Biochem Biophys Res Commun 326:788-93 (2005). PubMed: 15607738
  • Bos R  et al. Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. Histopathology 46:31-6 (2005). PubMed: 15656883
  • Berger AP  et al. Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia. Prostate 57:57-65 (2003). PubMed: 12886524
  • Coradini D  et al. Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence. Br J Cancer 87:1105-11 (2002). PubMed: 12402149
  • Haugland HK  et al. Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: correlation with tumor oxygenation. Int J Radiat Oncol Biol Phys 53:854-61 (2002). PubMed: 12095550
  • Itoh T  et al. Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane. FEBS Lett 509:225-9 (2001). PubMed: 11741593
  • Duyndam MC  et al. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem 276:48066-76 (2001). PubMed: 11641398
  • Gardner LB  et al. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276:7919-26 (2001). PubMed: 11112789
  • Yu F  et al. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein. Cancer Res 61:4136-42 (2001). PubMed: 11358837
  • Schindl M  et al. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol 19:799-802 (2001). PubMed: 11562758
  • Volm M & Koomägi R Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 20:1527-33 (2000). PubMed: 10928066
  • Palmer LA  et al. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 58:1197-203 (2000). PubMed: 11093754
  • Ravi R  et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14:34-44 (2000). PubMed: 10640274
  • Zhong H  et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60:1541-5 (2000). PubMed: 10749120
  • Rivard A  et al. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem 275:29643-7 (2000). PubMed: 10882714
  • Chandel NS  et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275:25130-8 (2000). PubMed: 10833514
  • Agani FH  et al. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275:35863-7 (2000). PubMed: 10961998
  • Birner P  et al. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60:4693-6 (2000). PubMed: 10987269
  • Zhong H  et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5 (1999). PubMed: 10582706
  • Feldser D  et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 59:3915-8 (1999). PubMed: 10463582
  • Nguyen SV & Claycomb WC Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes. Biochem Biophys Res Commun 265:382-6 (1999). PubMed: 10558876

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