Anti-HIF-2-alpha antibody - ChIP Grade (ab199)

Publishing research using ab199? Please let us know so that we can cite the reference in this datasheet.

ab199 has been referenced in 45 publications.

  • Labrousse-Arias D  et al. HIF-2a-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res 109:115-30 (2016). Human . PubMed: 26503986
  • Zhu C  et al. Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK/ERK signaling pathway. Sci Rep 6:35489 (2016). ChIP ; Human . PubMed: 27765951
  • Ramakrishnan S  et al. HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. BMC Cancer 16:617 (2016). WB ; Human . PubMed: 27506904
  • Torres-Capelli M  et al. Role Of Hif2a Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation. Sci Rep 6:25357 (2016). IHC . PubMed: 27150457
  • Bourseau-Guilmain E  et al. Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells. Nat Commun 7:11371 (2016). WB . PubMed: 27094744
  • Lee KE  et al. Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia. Cancer Discov 6:256-69 (2016). IHC ; Mouse . PubMed: 26715642
  • Zhang J  et al. Hypoxia-Inducible Factor-2a Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol 27:92-106 (2016). Mouse . PubMed: 25956511
  • Alam MW  et al. HIF2a contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells. Oncotarget 7:11238-50 (2016). WB . PubMed: 26849233
  • Ning XH  et al. Association between FBP1 and hypoxia-related gene expression in clear cell renal cell carcinoma. Oncol Lett 11:4095-4098 (2016). PubMed: 27313747
  • Joseph JV  et al. Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1a-ZEB1 axis. Cancer Lett 359:107-16 (2015). PubMed: 25592037
  • Yamaleyeva LM  et al. Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Am J Physiol Endocrinol Metab 309:E84-94 (2015). PubMed: 25968580
  • Smith SJ  et al. Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response. Oncotarget 6:22191-205 (2015). IHC ; Human . PubMed: 26203665
  • Wu L  et al. HIF-2a mediates hypoxia-induced LIF expression in human colorectal cancer cells. Oncotarget 6:4406-17 (2015). WB, IHC . PubMed: 25726527
  • Razorenova OV  et al. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol 34:739-51 (2014). ChIP ; Human . PubMed: 24344197
  • Liu W  et al. Study on the expressions of PHD and HIF in placentas from normal pregnant women and patients with preeclampsia. Int J Biol Sci 10:278-84 (2014). WB, IHC-P ; Human . PubMed: 24644426
  • Storti F  et al. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica 99:e45-8 (2014). ChIP . PubMed: 24510339
  • Zecchini V  et al. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. EMBO J 33:1365-82 (2014). WB, ICC/IF . PubMed: 24837709
  • Rahtu-Korpela L  et al. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes 63:3324-33 (2014). PubMed: 24789921
  • Biswas S  et al. Insulin regulates hypoxia-inducible factor-1a transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte. PLoS One 8:e62128 (2013). WB ; Mouse . PubMed: 23626778
  • Taniguchi CM  et al. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nat Med 19:1325-30 (2013). PubMed: 24037093
  • Smeland E  et al. Prognostic impacts of hypoxic markers in soft tissue sarcoma. Sarcoma 2012:541650 (2012). PubMed: 22454562
  • Conley SJ  et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A 109:2784-9 (2012). WB . PubMed: 22308314
  • Stiehl DP  et al. Non-canonical HIF-2a function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop. Oncogene 31:2283-97 (2012). PubMed: 21927022
  • Zhang S  et al. Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2a activation. PLoS One 7:e29876 (2012). WB ; Mouse . PubMed: 22295069
  • Yu X  et al. The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration. Nephrol Dial Transplant : (2012). WB ; Rat . PubMed: 22399494
  • Perier A  et al. Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma. Oncogene 30:2622-32 (2011). PubMed: 21258414
  • Weir L  et al. Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes. Biochim Biophys Acta 1813:60-72 (2011). PubMed: 21129412
  • Vanhorebeek I  et al. Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab 96:E633-45 (2011). WB ; Human . PubMed: 21270330
  • Andersen S  et al. Diverging prognostic impacts of hypoxic markers according to NSCLC histology. Lung Cancer 72:294-302 (2011). PubMed: 21075472
  • Guadall A  et al. Fibulin-5 Is Up-regulated by Hypoxia in Endothelial Cells through a Hypoxia-inducible Factor-1 (HIF-1α)-dependent Mechanism. J Biol Chem 286:7093-103 (2011). PubMed: 21193390
  • Martin SK  et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica 95:776-84 (2010). ChIP ; Human . PubMed: 20015878
  • Moreno-Manzano V  et al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem 285:1333-42 (2010). WB, ChIP ; Human . PubMed: 19897487
  • Yuen JS  et al. Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer. Mol Cancer Ther 8:1448-59 (2009). WB ; Human . PubMed: 19509240
  • Song Y  et al. Sp-1 and c-Myc mediate lysophosphatidic acid-induced expression of vascular endothelial growth factor in ovarian cancer cells via a hypoxia-inducible factor-1-independent mechanism. Clin Cancer Res 15:492-501 (2009). WB ; Human . PubMed: 19147754
  • Favier J  et al. The warburg effect is genetically determined in inherited pheochromocytomas. PLoS One 4:e7094 (2009). IHC-P ; Human . PubMed: 19763184
  • Carroll VA & Ashcroft M Regulation of angiogenic factors by HDM2 in renal cell carcinoma. Cancer Res 68:545-52 (2008). WB ; Human . PubMed: 18199551
  • Cervera AM  et al. Cells silenced for SDHB expression display characteristic features of the tumor phenotype. Cancer Res 68:4058-67 (2008). WB ; Human . PubMed: 18519664
  • Bacon AL  et al. Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Oncogene 26:132-41 (2007). PubMed: 16799636
  • Thoma CR  et al. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol 9:588-95 (2007). WB ; Human . PubMed: 17450132
  • Echevarría M  et al. Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression. J Biol Chem 282:30207-15 (2007). WB ; Rat . PubMed: 17673462
  • Forooghian F  et al. Hypoxia-inducible factor expression in human RPE cells. Br J Ophthalmol 91:1406-10 (2007). PubMed: 17567660
  • Carroll VA & Ashcroft M Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Cancer Res 66:6264-70 (2006). WB ; Human . PubMed: 16778202
  • Grabmaier K  et al. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 23:5624-31 (2004). PubMed: 15184875
  • Gerald D  et al. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118:781-94 (2004). PubMed: 15369676
  • Klinger P  et al. Deletion of the oxygen-dependent degradation domain results in impaired transcriptional activity of hypoxia-inducible factors. Transcription 2:269-75 (0). PubMed: 22223045


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