General notesab94268 is a 293T cell transfected lysate in which Human HIP1R has been transiently over-expressed using a pCMV-HIP1R plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Tissue specificity: Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
Similarity: Belongs to the SLA2 family.
Contains 1 ENTH (epsin N-terminal homology) domain.
Contains 1 I/LWEQ domain.
Domain: Binds F-actin via the talin-like I/LWEQ domain.