Overview

  • Product nameAnti-HIPPI antibody
    See all HIPPI primary antibodies
  • Description
    Goat polyclonal to HIPPI
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Xenopus laevis
  • Immunogen

    Synthetic peptide:

    C-EQPQEYDDPNA

    , corresponding to internal sequence amino acids 103-113 of human HIPPI (NP_060480.1).

  • Positive control
    • Human and mouse brain lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab87623 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab87623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

Target

  • FunctionRequired for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
  • Tissue specificityPresent in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
  • Sequence similaritiesBelongs to the IFT57 family.
  • DomainThe pseudo DED region (pDED) meadiates the interaction with HIP1.
  • Cellular localizationCytoplasm > cytoskeleton > cilium basal body. Concentrates within the inner segment of cilia.
  • Information by UniProt
  • Database links
  • Alternative names
    • CDNA FLJ10147 fis clone HEMBA1003369 antibody
    • Dermal papilla derived protein 8 antibody
    • Dermal papilla-derived protein 8 antibody
    • DERP 8 antibody
    • DERP8 antibody
    • Esrrbl 1 antibody
    • Esrrbl1 antibody
    • ESRRBL1 protein antibody
    • Estrogen related receptor beta like 1 antibody
    • Estrogen related receptor beta like protein 1 antibody
    • Estrogen-related receptor beta-like protein 1 antibody
    • FLJ10147 antibody
    • Hip1 Interacting protein antibody
    • HIP1 interacting protein HIPPI antibody
    • Hip1 protein interactor antibody
    • HIP1-interacting protein antibody
    • HIPPI antibody
    • Huntingtin interacting protein 1 interacting protein antibody
    • Huntingtin interacting protein 1 protein interactor antibody
    • IFT 57 antibody
    • ift57 antibody
    • IFT57_HUMAN antibody
    • Intraflagellar transport 57 homolog (Chlamydomonas) antibody
    • Intraflagellar transport 57 homolog antibody
    • Intraflagellar transport protein 57 homolog antibody
    • MHS4R2 antibody
    • Vestrogen related receptor beta like 1 antibody
    see all

Anti-HIPPI antibody images

  • Anti-HIPPI antibody (ab87623) at 1 µg/ml + mouse brain lysate (in RIPA buffer) at 35 µg

    Predicted band size : 49 kDa
    Observed band size : 49 kDa

References for Anti-HIPPI antibody (ab87623)

ab87623 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"