Overview

  • Product nameAnti-HIRA antibody [374C6a]
    See all HIRA primary antibodies
  • Description
    Mouse monoclonal [374C6a] to HIRA
  • Tested applicationsSuitable for: WB, Dot blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment derived from internal sequence of human HIRA

  • Positive control
    • Recombinant human HIRA.

Properties

Applications

Our Abpromise guarantee covers the use of ab70734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 112 kDa.
Dot blot Use at an assay dependent dilution.

Target

  • FunctionCooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
  • Tissue specificityExpressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.
  • Sequence similaritiesBelongs to the WD repeat HIR1 family.
    Contains 8 WD repeats.
  • Developmental stageExpressed during embryogenesis.
  • Post-translational
    modifications
    Sumoylated.
    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.
  • Cellular localizationNucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
  • Information by UniProt
  • Database links
  • Alternative names
    • DGCR1 antibody
    • DiGeorge critical region gene 1 antibody
    • HIR antibody
    • HIR histone cell cycle regulation defective homolog A antibody
    • HIRA antibody
    • HIRA protein antibody
    • HIRA_HUMAN antibody
    • Histone cell cycle regulator antibody
    • Protein HIRA antibody
    • TUP 1 antibody
    • TUP1 like enhancer of split protein 1 antibody
    • TUP1-like enhancer of split protein 1 antibody
    • TUPLE1 antibody
    see all

Anti-HIRA antibody [374C6a] images

References for Anti-HIRA antibody [374C6a] (ab70734)

ab70734 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab70734.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"