• Product nameAnti-HIST1H2AK antibody
    See all HIST1H2AK primary antibodies
  • Description
    Rabbit polyclonal to HIST1H2AK
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human HIST1H2AK aa 1-130 (internal sequence) (unmodified ). Synthetic peptide from an internal sequence of the Human HIST1H2AK protein (P0C0S8).


    Database link: P0C0S8

  • Positive control
    • Human colon carcinoma tissue.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: PBS without calcium and magnesium
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesAffinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab110978 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • Sequence similaritiesBelongs to the histone H2A family.
  • Post-translational
    The chromatin-associated form is phosphorylated on Thr-121 during mitosis.
    Deiminated on Arg-4 in granulocytes upon calcium entry.
    Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.
    Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.
    Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Cellular localizationNucleus. Chromosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • H2A histone family, member P antibody
    • H2A.1 antibody
    • H2A.1b antibody
    • H2A/n antibody
    • H2A/p antibody
    • H2A1_HUMAN antibody
    • H2AF antibody
    • H2AFC antibody
    • H2AFD ANDHIST1H2AL antibody
    • H2AFD antibody
    • H2AFI antibody
    • H2AFN ANDHIST1H2AG antibody
    • H2AFN antibody
    • H2AFP antibody
    • HIST1H2AI antibody
    • HIST1H2AJ antibody
    • HIST1H2AK antibody
    • HIST1H2AL antibody
    • HIST1H2AM antibody
    • Histone 1, H2ag antibody
    • Histone cluster 1, H2ag antibody
    • Histone H2A type 1 antibody
    • Histone H2A.c/d/i/n/p antibody
    • Histone H2A/p antibody
    • pH2A/f antibody
    see all

Anti-HIST1H2AK antibody images

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using HIST1H2AK antibody (ab110978). Without peptide blocking on left and with peptide blocking on the right.

References for Anti-HIST1H2AK antibody (ab110978)

ab110978 has not yet been referenced specifically in any publications.

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