Overview

  • Product name
    Histamine
  • Description
    Potent vasodilator and endogenous histamine receptor agonist.
  • Alternative names
    • 1H-Imidazole-4-ethanamine
    • 2-(4-Imidazolyl)ethylamine
    • Ergotidine
    • Histamine, free base
    • L-Histamine
    see all
  • Biological description

    Potent vasodilator. Formed by the decarboxylation of L-histidine. Acts as an agonist for endogenous histamine receptors. Histamine H1 receptor activation mobilizes Ca2+; H2 activation stimulates adenylate cyclase activity in neurons. Activates nitric oxide synthase (NOS).

Properties

  • Molecular weight
    111.10
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C5H9N3
  • CAS Number
    51-45-6
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Izumi H  et al. Role of nitric oxide on vasorelaxation in human umbilical artery. Am J Obstet Gynecol 172:1477-84 (1995). Read more (PubMed: 7755057) »
  • Vannier E & Dinarello CA Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. J Biol Chem 269:9952-6 (1994). Read more (PubMed: 7511596) »
  • Yan ZQ  et al. The involvement of nitric oxide synthase in the effect of histamine on guinea-pig airway smooth muscle in vitro. Agents Actions 41 Spec No:C111-2 (1994). Read more (PubMed: 7526640) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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