Anti-Histone acetyltransferase MYST3 antibody (ab110945)

Overview

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab110945 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
    • Involvement in disease
      Note=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
      Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
    • Sequence similarities
      Belongs to the MYST (SAS/MOZ) family.
      Contains 1 C2HC-type zinc finger.
      Contains 1 H15 (linker histone H1/H5 globular) domain.
      Contains 2 PHD-type zinc fingers.
    • Domain
      The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
    • Post-translational
      modifications
      Autoacetylated.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
    • Information by UniProt
    • Database links
    • Alternative names
      • HAT 3 antibody
      • Histone acetyltransferase MYST3 antibody
      • Monocytic leukemia zinc finger protein antibody
      • MOZ antibody
      • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 antibody
      • MYST histone acetyltransferase (monocytic leukemia) 3 antibody
      • MYST protein 3 antibody
      • MYST-3 antibody
      • MYST3 antibody
      • MYST3_HUMAN antibody
      • OTTHUMP00000197392 antibody
      • OTTHUMP00000197394 antibody
      • OTTHUMP00000225722 antibody
      • Runt related transcription factor binding protein 2 antibody
      • Runt-related transcription factor-binding protein 2 antibody
      • RUNXBP2 antibody
      • SAS2 antibody
      • SAS2 and TIP60 protein 3 antibody
      • TIP60 protein 3 antibody
      • YBF2/SAS3 antibody
      • ZC2HC6A antibody
      • Zinc finger protein 220 antibody
      • ZNF220 antibody
      see all

    Images

    • ab110945, at 3.75µg/ml, staining KAT6A / HAT3 in formalin-fixed, paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

    References

    ab110945 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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