Anti-Histone H2A.X antibody - ChIP Grade (ab11175)

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ab11175 has been referenced in 34 publications.

  • Piya S  et al. Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood 128:1260-9 (2016). PubMed: 27268264
  • Kocylowski MK  et al. Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle 14:1748-58 (2015). WB ; Human . PubMed: 25695757
  • Huang SC  et al. Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis. Sci Signal 7:ra20 (2014). PubMed: 24570488
  • Leung JW  et al. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet 10:e1004178 (2014). WB ; Human . PubMed: 24603765
  • Shahar OD  et al. A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. Nucleic Acids Res 42:5689-701 (2014). WB ; Human . PubMed: 24682826
  • Goshima T  et al. Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-?B signaling pathway. J Biol Chem 289:11656-66 (2014). WB ; Human . PubMed: 24584930
  • Oleson BJ  et al. Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent ?H2AX protein formation in pancreatic ß cells. J Biol Chem 289:11454-64 (2014). WB ; Rat . PubMed: 24610783
  • Inoue A & Zhang Y Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes. Nat Struct Mol Biol 21:609-16 (2014). IHC - Wholemount, ICC/IF ; Mouse . PubMed: 24908396
  • Knobel PA  et al. USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol 34:2062-74 (2014). WB . PubMed: 24687851
  • Sabirzhanov B  et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci 34:10055-71 (2014). Mouse . PubMed: 25057207
  • Mamouni K  et al. RhoB promotes ?H2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol 34:3144-55 (2014). PubMed: 24912678
  • Castillo J  et al. Genomic and proteomic dissection and characterization of the human sperm chromatin. Mol Hum Reprod 20:1041-53 (2014). PubMed: 25193639
  • Katsogiannou M  et al. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol Cell Proteomics 13:3585-601 (2014). WB . PubMed: 25277244
  • Henriksson S  et al. The scaffold protein WRAP53ß orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev 28:2726-38 (2014). Human . PubMed: 25512560
  • Soldi M & Bonaldi T The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components. Mol Cell Proteomics 12:764-80 (2013). WB, ChIP . PubMed: 23319141
  • Castro-Vega LJ  et al. Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis N/A:N/A (2013). Human . PubMed: 23358853
  • Mahen R  et al. A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei. PLoS One 8:e61893 (2013). WB, ICC/IF . PubMed: 23658700
  • Britton S  et al. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol 202:579-95 (2013). PubMed: 23897892
  • Seo J  et al. Genome-wide reorganization of histone H2AX toward particular fragile sites on cell activation. Nucleic Acids Res N/A:N/A (2013). WB, ChIP ; Human . PubMed: 24163101
  • Sparks A  et al. The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene N/A:N/A (2013). Human . PubMed: 24121268
  • Mehrotra PV  et al. DNA Repair Factor APLF Is a Histone Chaperone. Mol Cell 41:46-55 (2011). ICC/IF ; Human . PubMed: 21211722
  • Iwamori N  et al. The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod 84:1225-34 (2011). PubMed: 21293030
  • Fiedler J  et al. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124:720-30 (2011). WB, IHC-Fr ; Mouse . PubMed: 21788589
  • Wu M  et al. Selenium compounds activate early barriers of tumorigenesis. J Biol Chem 285:12055-62 (2010). ICC/IF ; Human . PubMed: 20157118
  • Dimitrova N & de Lange T Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol 29:5552-63 (2009). WB ; Mouse . PubMed: 19667071
  • Lee JH  et al. Chromatin analysis of occluded genes. Hum Mol Genet 18:2567-74 (2009). ChIP ; Human . PubMed: 19380460
  • Cook PJ  et al. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458:591-6 (2009). PubMed: 19234442
  • Dawson MA  et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461:819-22 (2009). WB ; Human . PubMed: 19783980
  • Tjeertes JV  et al. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J 28:1878-89 (2009). WB ; Human . PubMed: 19407812
  • Ziegler-Birling C  et al. Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage. Int J Dev Biol 53:1003-11 (2009). Mouse . PubMed: 19598117
  • Guervilly JH  et al. Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. Hum Mol Genet 17:679-89 (2008). PubMed: 18029388
  • Mu W  et al. An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol 28:6439-51 (2008). WB ; Mouse . PubMed: 18710940
  • Dimitrova N & de Lange T MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev 20:3238-43 (2006). PubMed: 17158742
  • Cowell IG  et al. Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated. Biochem Pharmacol 71:13-20 (2005). PubMed: 16293233