The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityImmunoreactive with all sera of HIV type O infected individuals.
Immunoreactive with all sera of HIV type O infected individuals.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
RelevanceThe transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
Cellular localizationCell membrane
References for HIV gp41 L peptide (ab43148)
has not yet been referenced specifically in any publications.
Publishing research using ab43148? Please let us know so that we can cite the reference in this datasheet.
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