Overview

  • Product nameAnti-HIV1 integrase antibody [IN-2]
  • Description
    Mouse monoclonal [IN-2] to HIV1 integrase
  • Specificityab66645 is specific for bacterial HIV1 integrase (IN) protein.
  • Tested applicationsSuitable for: WB, ICC/IF, IPmore details
  • Species reactivity
    Reacts with HIV1.
  • Immunogen

    Bacterially expressed, hexahistidine amino-terminal tagged HIV1 integrase (IN) protein (clade B, HXB-3 isolate)

Properties

Applications

Our Abpromise guarantee covers the use of ab66645 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 32 kDa.
ICC/IF Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

Target

  • RelevanceIntegrase is an enzyme, a product of the HIV1 Gag/Pol gene; the other two enzymes being reverse transcriptase and protease. The human immunodeficiency virus (HIV-1) uses an enzyme, a so-called integrase, to carry out the integration of its viral DNA into the host chromosome thereby tricking the host cell machinery into making viral proteins. The HIV-1 integrase is a protein of 32 kDa and is composed of three domains. No cellular homologue of HIV integrase has been described, so potential inhibitors to this enzyme could be relatively nontoxic.
  • Alternative names
    • HIV antibody
    • Human Immunodeficiency virus 1 antibody
    • IN antibody
    • Integrase antibody

References for Anti-HIV1 integrase antibody [IN-2] (ab66645)

This product has been referenced in:
  • Desimmie BA  et al. LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions. Retrovirology 10:57 (2013). WB . Read more (PubMed: 23721378) »

See 1 Publication for this product

Product Wall

Thank you for contacting us. The amino acid sequence we used to produce this antibody is "FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQL". This sequence is compatible to the amino acid 1148 to 1210 of Gag-Pol protein clad B P04585....

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"