Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab63996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % by SDS-PAGE.
    Highly purified by several steps of chromatography.
  • FormLiquid
  • Additional Notesab63996 has been derived from infectious plasmid clone pNL4-3 and belongs to Group B of HIV-1.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 7.5

General info

  • Alternative names
    • C terminal core protein
    • F protein
    • Nef
    • Negative factor
    • p27
    see all
  • RelevanceNef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.

HIV1 Nef full length protein images

  • Polyacrylamide gel electrophoresis of ab63996.

References for HIV1 Nef full length protein (ab63996)

ab63996 has not yet been referenced specifically in any publications.

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