HIV1 Nef full length protein (ab63996)
- Product nameHIV1 Nef full length proteinSee all HIV1 Nef proteins and peptides ...
- SourceE. coli
- Amino Acid Sequence
- Amino acids0 to 0
Our Abpromise guarantee covers the use of ab63996 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Purity> 90
% by SDS-PAGE.
Highly purified by several steps of chromatography.
- Additional Notesab63996 has been derived from infectious plasmid clone pNL4-3 and belongs to Group B of HIV-1.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 50% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 7.5
- C terminal core protein
- F protein
- Negative factor
- RelevanceNef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.
References for HIV1 Nef full length protein (ab63996)
ab63996 has not yet been referenced specifically in any publications.