• Product nameAnti-HIVEP3 antibody
  • Description
    Rabbit polyclonal to HIVEP3
  • Tested applicationsSuitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 560-707 of Human HIVEP3.

  • Positive control
    • Human rectum tissue.


Associated products


Our Abpromise guarantee covers the use of ab121229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionPlays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; Trough non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
  • Sequence similaritiesContains 5 C2H2-type zinc fingers.
  • DomainThe ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.
  • Post-translational
    Phosphorylated on threonine and serine residues.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ16752 antibody
    • Hivep3 antibody
    • Human immunodeficiency virus type I enhancer-binding protein 3 antibody
    • Kappa-B and V(D)J recombination signal sequences-binding protein antibody
    • Kappa-binding protein 1 antibody
    • KBP-1 antibody
    • KIAA1555 antibody
    • KRC antibody
    • Schnurri-3 antibody
    • SHN3 antibody
    • Transcription factor HIVEP3 antibody
    • ZEP3_HUMAN antibody
    • Zinc finger protein ZAS3 antibody
    • ZNF40C antibody
    see all

Anti-HIVEP3 antibody images

  • Immunofluorescent staining of human cell line A-431 shows positivity in nucleus but excluded from the nucleoli.
  • ab121229 at 1/150 dilution, staining HIVEP3 in Human rectum tissue by Immunohistochemistry.

References for Anti-HIVEP3 antibody (ab121229)

ab121229 has not yet been referenced specifically in any publications.

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Expiration date: January 20th, 2013

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