This antibody can be used to distinguish true HLA B27 positives from false HLA B27 positives (i.e. HLA B7 positive) in the investigation of such diseases as ankylosing spondylitis and anterior uveitis.
Storage instructionsShipped at 4°C. Store at +4°C.
Purification notesThis antibody was purified from tissue culture supernatant.
Primary antibody notesThis antibody can be used to distinguish true HLA B27 positives from false HLA B27 positives (i.e. HLA B7 positive) in the investigation of such diseases as ankylosing spondylitis and anterior uveitis.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 10µl for 106 cells. (or 100µl whole blood)
ab91357-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
RelevanceHLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described.
Cellular localizationCell Membrane, single pass type I membrane protein.