Overview

  • Product nameAnti-HLA Class II DRB3 antibody
  • Description
    Rabbit polyclonal to HLA Class II DRB3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Amino acids 4 - 260 of Human HLA Class II DRB3 (NP_072049).

  • Positive control
    • A549 and HCT116 cell lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab98107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 30 kDa.

Target

  • RelevanceHLA Class II DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
  • Cellular localizationCell membrane; Endoplasmic reticulum membrane; Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Lysosome membrane; Late endosome membrane. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
  • Database links
  • Alternative names
    • HLA class II histocompatibility antigen DR beta 3 chain antibody
    • HLA DR3B antibody
    • HLADR3B antibody
    • Major histocompatibility complex, class II DR beta 3 antibody

Anti-HLA Class II DRB3 antibody images

  • Anti-HLA Class II DRB3 antibody (ab98107) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 30 kDa

References for Anti-HLA Class II DRB3 antibody (ab98107)

ab98107 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"