Overview

  • Product name
    Anti-HLA DMA antibody
  • Description
    Rabbit polyclonal to HLA DMA
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human HLA DMA aa 52-255.
    Database link: AAH11447

  • Positive control
    • WB: HeLa whole cell lysates. IHC-P: Human breast cancer tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab96664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 29 kDa.
IHC-P 1/250.

Target

  • Relevance
    Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing. HLA DM plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.
  • Cellular localization
    Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: Localizes to late endocytic compartment. Associates with lysosome membranes.
  • Database links
  • Alternative names
    • Class II histocompatibility antigen M alpha chain antibody
    • D6S222E antibody
    • DMA antibody
    • HLA class II histocompatibility antigen DM alpha chain antibody
    • HLA DMA antibody
    • HLADM antibody
    • Major histocompatibility complex class II DM alpha antibody
    • MHC class II antigen DMA antibody
    • OTTHUMP00000029242 antibody
    • OTTHUMP00000062997 antibody
    • OTTHUMP00000178727 antibody
    • OTTHUMP00000178728 antibody
    • OTTHUMP00000178729 antibody
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    • Ring 6 antibody
    • Ring6 antibody
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Images

  • Anti-HLA DMA antibody (ab96664) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 29 kDa
    12% SDS PAGE
  • Immunohistochemical (Formalin/PFA-fixed pparaffin-embedded) analysis of human breast cancer tissue labelling HLA DMA with ab96664 at a 1/250 dilution.

References

ab96664 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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