Overview

  • Product nameAnti-HLA DMB antibody
    See all HLA DMB primary antibodies
  • Description
    Rabbit polyclonal to HLA DMB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 40-89 (FTYCISFNKD LLTCWDPEEN KMAPCEFGVL NSLANVLSQH LNQKDTLMQR) of Human HLA DMB (NP_002109).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferConstituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab125387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 29 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceHLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
  • Cellular localizationLate endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
  • Database links
  • Alternative names
    • class II antigen HLA-DM beta chain antibody
    • class II histocompatibility antigen antibody
    • Class II histocompatibility antigen M beta chain antibody
    • D6S221E antibody
    • DMB antibody
    • HLA class II histocompatibility antigen DM beta chain antibody
    • HLA-DM histocompatibility type, beta chain antibody
    • M beta chain antibody
    • Major histocompatibility complex class II DM beta antibody
    • MHC class II antigen DMB antibody
    • MHC class II antigen HLA DM beta chain antibody
    • MHC class II HLA DMB antibody
    • OTTHUMP00000029257 antibody
    • Really interesting new gene 7 protein antibody
    • RING 7 antibody
    • RING7 antibody
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Anti-HLA DMB antibody images

  • Anti-HLA DMB antibody (ab125387) at 1 µg/ml + Human placenta

    Predicted band size : 29 kDa

References for Anti-HLA DMB antibody (ab125387)

ab125387 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"