Overview

  • Product nameAnti-HLA DR + HLA DP antibody [HL-38]
    See all HLA DR + HLA DP primary antibodies
  • Description
    Mouse monoclonal [HL-38] to HLA DR + HLA DP
  • SpecificityThe antibody also reacts with porcine MHC class II antigens (SLA-D gene products).
  • Tested applicationsSuitable for: Flow Cyt, IP, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue/ cell preparation (Human). (Burkitt lymphoma cell line Raji).

  • EpitopeThis antibody binds to a common epitope on the b-chain of human HLA-DR and HLA-DP.

Properties

Applications

Our Abpromise guarantee covers the use of ab766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IP
WB
  • Application notesFlow Cyt: Use at an assay dependant concentration.
    IP: Use at an assay dependant concentration.
    WB: Use at an assay dependant concentration. Use under non-reducing conditions.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceHuman MHC class II antigens are transmembrane glycoproteins composed of an alpha (36 kDa) and a beta chain (27kDa) and are expressed primarily on antigen presenting cells. Human MHC class II genes are located in the HLA-D region that encodes at least 6 alpha and 10 beta chain genes. Three loci, DR, DQ and DP, encode the major products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells and therefore have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
    • Cellular localizationCell Membrane; Single pass type I membrane protein
    • Database links
    • Alternative names
      • HLA DP antibody
      • HLA DR antibody
      • MHC Class II antibody

    References for Anti-HLA DR + HLA DP antibody [HL-38] (ab766)

    This product has been referenced in:
    • Horejsi­ V  et al. Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen. Folia Biol (Praha) 32:12-25 (1986). Read more (PubMed: 2422063) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"