Anti-HLA DR + HLA DP antibody [MEM-136] (ab8094)

Overview

  • Product nameAnti-HLA DR + HLA DP antibody [MEM-136]
    See all HLA DR + HLA DP primary antibodies
  • Description
    Mouse monoclonal [MEM-136] to HLA DR + HLA DP
  • SpecificityCommon epitope on b-chain of human HLA-DR and HLA-DP. Reacts with alpha-beta dimer as well as with dissociated beta subunit.
  • Tested applicationsSuitable for: Flow Cyt, IP, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human HLA DR + HLA DP.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • Purity>95% by SDS-PAGE
  • Purification notesPurified from ascites using protein A affinity chromatography.
  • ClonalityMonoclonal
  • Clone numberMEM-136
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab8094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 0.5 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Use under non reducing condition. Detects a band of approximately 23 kDa.

Target

  • RelevanceHuman MHC class II antigens are transmembrane glycoproteins composed of an alpha (36 kDa) and a beta chain (27kDa) and are expressed primarily on antigen presenting cells. Human MHC class II genes are located in the HLA-D region that encodes at least 6 alpha and 10 beta chain genes. Three loci, DR, DQ and DP, encode the major products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells and therefore have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
  • Cellular localizationCell Membrane; Single pass type I membrane protein
  • Database links
  • Alternative names
    • HLA DP antibody
    • HLA DR antibody
    • MHC Class II antibody

References for Anti-HLA DR + HLA DP antibody [MEM-136] (ab8094)

ab8094 has not yet been referenced specifically in any publications.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"