Anti-HMGA2 antibody, prediluted (ab52089)

Overview

  • Product nameAnti-HMGA2 antibody, prediluted
    See all HMGA2 primary antibodies
  • Description
    Rabbit polyclonal to HMGA2, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to C-terminal of human HMGA2.

  • Positive control
    • SW579 cells and Breast carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab52089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.

Target

  • FunctionFunctions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
  • Involvement in diseaseNote=A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.
    Note=A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.
    Note=A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.
    Note=A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.
  • Sequence similaritiesBelongs to the HMGA family.
    Contains 3 A.T hook DNA-binding domains.
  • Developmental stageExpressed predominantly during embryogenesis.
  • Post-translational
    modifications
    Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • HMGA 2 antibody
    • BABL antibody
    • High mobility group (nonhistone chromosomal) protein isoform I C antibody
    • High mobility group (nonhistone chromosomal) protein isoform IC antibody
    • High Mobility Group AT hook 2 antibody
    • High Mobility Group AT hook protein 2 antibody
    • High mobility group AT-hook protein 2 antibody
    • High mobility group protein HMGI C antibody
    • High mobility group protein HMGI-C antibody
    • High mobility group protein HMGIC antibody
    • High mobility group protein I, isoform C antibody
    • HMGA2 antibody
    • HMGA2_HUMAN antibody
    • HMGI C antibody
    • HMGIC antibody
    • LIPO antibody
    • Non histone chromosomal architectural protein HMGI C antibody
    • Non histone chromosomal architectural protein HMGIC antibody
    • Pygmy antibody
    • STQTL9 antibody
    see all

Anti-HMGA2 antibody, prediluted images

  • Staining of HMGA2 in human breast carcinoma by immunohistochemistry (formalin fixed, paraffin embedded section) using ab52089 (prediluted).

References for Anti-HMGA2 antibody, prediluted (ab52089)

ab52089 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Epithelial layer of tonsil)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: EDTA, pH9.0, 20 min, 100C
Permeabilization No
Specification Epithelial layer of tonsil
Blocking step H2O2 as blocking agent for 10 minute(s) · Concentration: 3% · Temperature: 25°C
Fixative Formaldehyde
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Submitted Dec 02 2016

Thank you for contacting us.

ab52089 (rabbit polyclonal to HMGA2) is a prediluted antibody that is ready to use. No further treatment is required.

However,the product is not suitable for diagnostic purposes. Please note all produc...

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