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ab18256 has been referenced in 76 publications.

  • Xiong X  et al. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation 13:241 (2016). WB ; Rat . PubMed: 27609334
  • Norouzitallab P  et al. Non-lethal heat shock induces HSP70 and HMGB1 protein production sequentially to protect Artemia franciscana against Vibrio campbellii. Fish Shellfish Immunol 42:395-9 (2015). PubMed: 25463291
  • Aslani F  et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Hum Reprod 30:417-31 (2015). PubMed: 25452436
  • Gustin A  et al. NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PLoS One 10:e0130624 (2015). ICC . PubMed: 26091541
  • Hasan M  et al. Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice. J Immunol 195:4573-7 (2015). PubMed: 26432890
  • Yang L  et al. PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Nat Commun 5:4436 (2014). WB ; Mouse . PubMed: 25019241
  • Weber DJ  et al. The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation. Sci Transl Med 6:252ra124 (2014). PubMed: 25186179
  • Su Z  et al. Up-regulated HMGB1 in EAM directly led to collagen deposition by a PKCß/Erk1/2-dependent pathway: cardiac fibroblast/myofibroblast might be another source of HMGB1. J Cell Mol Med 18:1740-51 (2014). ICC/IF ; Mouse . PubMed: 24912759
  • Ebrahimkhani MR  et al. Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci U S A 111:E4878-86 (2014). PubMed: 25349415
  • Xu H  et al. High mobility group box 1 release from cholangiocytes in patients with acute-on-chronic liver failure. Exp Ther Med 8:1178-1184 (2014). IHC ; Human . PubMed: 25187820
  • Tomasella A  et al. A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1. J Biol Chem 289:25699-710 (2014). Human . PubMed: 25096578
  • Peeters PM  et al. Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs. Part Fibre Toxicol 11:58 (2014). ELISA, IHC-P ; Human . PubMed: 25406505
  • Yang PS  et al. Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats. Respir Res 15:148 (2014). ELISA, IHC-Fr ; Rat . PubMed: 25420924
  • Johansson L  et al. HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes. Front Cell Infect Microbiol 4:4 (2014). IHC-Fr ; Human . PubMed: 24524027
  • Santos AR  et al. Cellular mechanisms of high mobility group 1 (HMGB-1) protein action in the diabetic retinopathy. PLoS One 9:e87574 (2014). WB ; Mouse . PubMed: 24498140
  • Lu B  et al. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. Proc Natl Acad Sci U S A 111:3068-73 (2014). IP ; Mouse . PubMed: 24469805
  • Van Opdenbosch N  et al. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun 5:3209 (2014). WB ; Mouse . PubMed: 24492532
  • Parasa VR  et al. Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue. Dis Model Mech 7:281-8 (2014). IHC-Fr ; Human . PubMed: 24203885
  • Zou JY & Crews FT Release of neuronal HMGB1 by Ethanol through decreased HDAC activity activates brain neuroimmune signaling. PLoS One 9:e87915 (2014). WB ; Human . PubMed: 24551070
  • Nogueira AV  et al. HMGB1 localization during experimental periodontitis. Mediators Inflamm 2014:816320 (2014). WB ; Mouse, Rat . PubMed: 24692854
  • Gong G  et al. Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats. PLoS One 9:e89450 (2014). WB, IHC-FoFr ; Rat . PubMed: 24594628
  • Miller JM  et al. Curcumin: a double hit on malignant mesothelioma. Cancer Prev Res (Phila) 7:330-40 (2014). PubMed: 24431405
  • Qiu Y  et al. HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresia. PLoS Pathog 10:e1004011 (2014). IF ; Mouse . PubMed: 24651485
  • Kuroda N  et al. Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition. PLoS One 9:e92884 (2014). IHC-P, ChIP ; Mouse . PubMed: 24690901
  • Zhu Z  et al. Haploinsufficiency of Def Activates p53-Dependent TGFß Signalling and Causes Scar Formation after Partial Hepatectomy. PLoS One 9:e96576 (2014). WB, ICC/IF ; Zebrafish . PubMed: 24801718
  • Zhao C  et al. Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation. J Biol Chem 289:17020-17029 (2014). WB . PubMed: 24798340
  • Choy M  et al. A novel, noninvasive, predictive epilepsy biomarker with clinical potential. J Neurosci 34:8672-84 (2014). PubMed: 24966369
  • Müller MC  et al. Contribution of damage-associated molecular patterns to transfusion-related acute lung injury in cardiac surgery. Blood Transfus 12:368-75 (2014). WB ; Human . PubMed: 24887223
  • Ge X  et al. High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD). J Biol Chem 289:22672-91 (2014). IHC-P ; Human . PubMed: 24928512
  • Gu L  et al. T cells contribute to stroke-induced lymphopenia in rats. PLoS One 8:e59602 (2013). WB ; Rat . PubMed: 23555048
  • Crnogorac-Jurcevic T  et al. Molecular analysis of precursor lesions in familial pancreatic cancer. PLoS One 8:e54830 (2013). IHC-P ; Human . PubMed: 23372777
  • Melis MH  et al. Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response. Cell Death Differ 20:765-73 (2013). Mouse . PubMed: 23412345
  • Simpson KL  et al. A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis 4:e613 (2013). WB, ELISA, IHC-P ; Mouse, Human . PubMed: 23640455
  • Fang H  et al. Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis 4:e694 (2013). PubMed: 23807223
  • Lippai D  et al. Alcohol-induced IL-1ß in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J Leukoc Biol 94:171-82 (2013). PubMed: 23625200
  • Lee Y  et al. Clinical significance of serum high-mobility group box 1 level in alopecia areata. J Am Acad Dermatol 69:742-7 (2013). PubMed: 23932647
  • Hillegass JM  et al. Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells. Part Fibre Toxicol 10:39 (2013). WB ; Human . PubMed: 23937860
  • Vu K  et al. Cryptococcus neoformans promotes its transmigration into the central nervous system by inducing molecular and cellular changes in brain endothelial cells. Infect Immun 81:3139-47 (2013). PubMed: 23774597
  • Whilding LM  et al. Vaccinia virus induces programmed necrosis in ovarian cancer cells. Mol Ther 21:2074-86 (2013). WB . PubMed: 23985697
  • Niedelman W  et al. Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun 81:4341-9 (2013). Human . PubMed: 24042117
  • Rabadi MM  et al. Interaction between uric acid and HMGB1 translocation and release from endothelial cells. Am J Physiol Renal Physiol 302:F730-41 (2012). WB ; Human . PubMed: 22189943
  • Kouzaki H  et al. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 186:4375-87 (2011). PubMed: 21357533
  • Wang HL  et al. The inhibitory effect of lidocaine on the release of high mobility group box 1 in lipopolysaccharide-stimulated macrophages. Anesth Analg 112:839-44 (2011). PubMed: 21288974
  • Zurolo E  et al. Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain 134:1015-32 (2011). PubMed: 21414994
  • Li J  et al. Neutralization of the extracellular HMGB1 released by ischaemic damaged renal cells protects against renal ischaemia-reperfusion injury. Nephrol Dial Transplant 26:469-78 (2011). IHC-P ; Mouse . PubMed: 20679140
  • Xu H  et al. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. Am J Physiol Heart Circ Physiol 300:H913-21 (2011). PubMed: 21186276
  • Wang L  et al. Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression. Neurosci Lett 471:152-6 (2010). WB, IHC-FoFr ; Rat . PubMed: 20100543
  • Ferhani N  et al. Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in COPD. Am J Respir Crit Care Med : (2010). PubMed: 20133931
  • Yu H  et al. Role of high-mobility group box 1 protein and poly(ADP-ribose) polymerase 1 degradation in Chlamydia trachomatis-induced cytopathicity. Infect Immun 78:3288-97 (2010). WB, ELISA ; Human . PubMed: 20421386
  • Ramos L  et al. Mast cell stabilization improves survival by preventing apoptosis in sepsis. J Immunol 185:709-16 (2010). ELISA ; Mouse . PubMed: 20519642
  • Mittal D  et al. TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J 29:2242-52 (2010). IHC-P ; Mouse . PubMed: 20526283
  • Lamkanfi M  et al. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 185:4385-92 (2010). ICC/IF ; Mouse . PubMed: 20802146
  • Xu H  et al. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol 184:1492-8 (2010). WB, ELISA, IHC-Fr ; Mouse . PubMed: 20028656
  • Tesniere A  et al. Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene 29:482-91 (2010). ICC/IF . PubMed: 19881547
  • Chalmin F  et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 120:457-71 (2010). WB . PubMed: 20093776
  • Laserna EJ  et al. Proteomic analysis of phosphorylated nuclear proteins underscores novel roles for rapid actions of retinoic acid in the regulation of mRNA splicing and translation. Mol Endocrinol 23:1799-814 (2009). PubMed: 19812389
  • Leemans JC  et al. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. PLoS One 4:e5704 (2009). IHC-P ; Mouse . PubMed: 19479087
  • Cayrol C & Girard JP The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A 106:9021-6 (2009). WB ; Human . PubMed: 19439663
  • Ito H  et al. Knock-down of PQBP1 impairs anxiety-related cognition in mouse. Hum Mol Genet 18:4239-54 (2009). WB ; Mouse . PubMed: 19661183
  • Yanai H  et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 462:99-103 (2009). WB ; Mouse . PubMed: 19890330
  • Liu H  et al. Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. Mol Cancer Res 7:1099-109 (2009). PubMed: 19584263
  • Krynetskaia NF  et al. Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther 8:864-72 (2009). WB ; Human . PubMed: 19372559
  • Youn JH  et al. High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-{alpha} Production in Human Monocytes. J Immunol 180:5067-74 (2008). ELISA ; Human . PubMed: 18354232
  • García-Escudero V  et al. Glioma regression in vitro and in vivo by a suicide combined treatment. Mol Cancer Res 6:407-17 (2008). PubMed: 18337448
  • Rittirsch D  et al. Functional roles for C5a receptors in sepsis. Nat Med 14:551-7 (2008). PubMed: 18454156
  • Andrassy M  et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 117:3216-26 (2008). PubMed: 18574060
  • Apetoh L  et al. Immunogenicity of anthracyclines: moving towards more personalized medicine. Trends Mol Med 14:141-51 (2008). PubMed: 18353726
  • Da Silva CA  et al. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol 181:4279-86 (2008). ELISA . PubMed: 18768886
  • Zhang X  et al. Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J Immunol 181:5015-23 (2008). WB, ICC/IF ; Mouse . PubMed: 18802105
  • Kappes F  et al. DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. Mol Cell Biol 28:3245-57 (2008). WB ; Human . PubMed: 18332104
  • Thorburn J  et al. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ : (2008). PubMed: 18846108
  • Rowe SM  et al. Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med 178:822-31 (2008). PubMed: 18658107
  • Brusa D  et al. Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity. Vaccine 26:6422-32 (2008). WB ; Human . PubMed: 18848858
  • Heo K  et al. Isolation and characterization of proteins associated with histone H3 tails in vivo. J Biol Chem 282:15476-83 (2007). PubMed: 17403666
  • Wu H  et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117:2847-59 (2007). IHC-P ; Mouse . PubMed: 17853945
  • Tracy K  et al. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 27:6229-42 (2007). ICC/IF ; Mouse . PubMed: 17576813

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