Overview

  • Product nameAnti-HMGCL antibody
    See all HMGCL primary antibodies
  • Description
    Mouse monoclonal to HMGCL
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-326 of Human HMGCL

Properties

Applications

Our Abpromise guarantee covers the use of ab55173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in the catabolism of branched amino acids such as leucine.
    • Tissue specificityFibroblasts, liver and lymphoblasts.
    • PathwayMetabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.
    • Involvement in diseaseDefects in HMGCL are the cause of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (HMGCLD) [MIM:246450]; also known as hydroxymethylglutaricaciduria or HL deficiency. An autosomal recessive disease affecting ketogenesis and L-leucine catabolism. The disease usually appears in the first year of life after a fasting period and its clinical acute symptoms include vomiting, seizures, metabolic acidosis, hypoketotic hypoglycemia and lethargy. These symptoms sometimes progress to coma, with fatal outcome in some cases.
    • Sequence similaritiesBelongs to the HMG-CoA lyase family.
    • Cellular localizationMitochondrion matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • 3 hydroxy 3 methylglutaryl CoA lyase antibody
      • 3 hydroxy 3 methylglutaryl Coenzyme A lyase antibody
      • 3 hydroxymethyl 3 methylglutaryl Coenzyme A lyase (hydroxymethylglutaricaciduria) antibody
      • 3 hydroxymethyl 3 methylglutaryl Coenzyme A lyase antibody
      • 3-hydroxy-3-methylglutarate-CoA lyase antibody
      • HL antibody
      • HMG CoA lyase antibody
      • HMG CoA Lyase Deficiency antibody
      • HMG-CoA lyase antibody
      • HMGCL antibody
      • HMGCL_HUMAN antibody
      • Hydroxymethylglutaricaciduria antibody
      • Hydroxymethylglutaryl CoA lyase antibody
      • Hydroxymethylglutaryl CoA lyase mitochondrial antibody
      • Hydroxymethylglutaryl-CoA lyase antibody
      • Mitochondrial 3 hydroxy 3 methylglutaryl CoA lyase antibody
      • mitochondrial antibody
      • MS725 antibody
      • OTTHUMP00000044830 antibody
      see all

    Anti-HMGCL antibody images



    • Predicted band size : 34 kDa
      HMGCL antibody (ab55173) at 1ug/lane + A-431 cell lysate at 25ug/lane.

    References for Anti-HMGCL antibody (ab55173)

    ab55173 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab55173.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"