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Product Name
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hnRNP M1-M4 antibody [3C181]
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See all hnRNP M1-M4 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [3C181] to hnRNP M1-M4
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Immunogen
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M19 fusion protein containing full length native protein (purified) (Human).
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Reacts with
(species key)
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Hu, Ms, Rat, Cow, Pig
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Specificity
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Specific for human RNP M1-M4.
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Tested applications
(see key)
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ELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/500 - 1/1000.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Chromatin and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Splicing
Chromatin and Nuclear Signaling >> DNA / RNA >> DNA / Nucleotides
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Relevance
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Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript specific packaging and alternative splicing of pre mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA binding proteins with greatest similarity to a hypothetical RNA binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64 kDa subunit of cleavage stimulation factor, which is involved in 3’ end maturation of pre mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
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hnRNP M1-M4 antibody [3C181] (ab4268) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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3C181
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Ascites
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Storage buffer
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Preservative: 0.1% Sodium Azide
Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.750 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this hnRNP M1-M4 antibody [3C181] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to hnRNP M1-M4
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hnRNP M1-M4 antibody [3C181] - more information
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