Anti-HNF1 beta antibody (ab119328)

Overview

  • Product nameAnti-HNF1 beta antibody
    See all HNF1 beta primary antibodies
  • Description
    Rabbit polyclonal to HNF1 beta
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, surrounding amino acids 252-256 (R-Q-K-N-P) of Human TCF2.

  • Positive control
    • HeLa, K562 and 3T3 cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab119328 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 45, 58, 61 kDa.

Target

  • FunctionTranscription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • Involvement in diseaseDefects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.
    Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
    Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:611955]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • Sequence similaritiesBelongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FJHN antibody
    • Hepatocyte nuclear factor 1 beta antibody
    • Hepatocyte nuclear factor 1-beta antibody
    • HNF 1B antibody
    • HNF 2 antibody
    • HNF-1-beta antibody
    • HNF-1B antibody
    • HNF1 beta antibody
    • HNF1 homeobox B antibody
    • HNF1B antibody
    • HNF1B_HUMAN antibody
    • HNF1beta antibody
    • HNF2 antibody
    • Homeoprotein LF B3 antibody
    • Homeoprotein LFB3 antibody
    • HPC11 antibody
    • LF B3 antibody
    • LFB3 antibody
    • MODY 5 antibody
    • MODY5 antibody
    • TCF 2 antibody
    • TCF 2 protein antibody
    • TCF-2 antibody
    • TCF2 antibody
    • TCF2 protein antibody
    • Transcription factor 2 antibody
    • Transcription factor 2 hepatic antibody
    • Variant hepatic nuclear factor 1 antibody
    • Variant hepatic nuclear factor antibody
    • VHNF 1 antibody
    • vHNF1 antibody
    see all

Anti-HNF1 beta antibody images

  • All lanes : Anti-HNF1 beta antibody (ab119328) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : K562 cell extract
    Lane 3 : 3T3 cell extract


    Predicted band size : 45, 58, 61 kDa

References for Anti-HNF1 beta antibody (ab119328)

ab119328 has not yet been referenced specifically in any publications.

Product Wall

Thank you very much for your interest in ab119328.

Indeed, we do have another antibody against TCF-2 which have been tested in IHC-P, the ab124351. It has however only been tested against the human protein. I am not sure whether this antibody...

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