Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous.
Contains 2 RRM (RNA recognition motif) domains.
Nucleus > nucleoplasm. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.
Western blot analysis using ab183654 at 1/200 dilution detecting hnRNP A2B1 in immunoprecipitation pellets from 4500 µg A549 whole cell lysate with ab183654 at 2 µg. Lane 2 shows Control with 2 μg of preimmune rabbit IgG.