• Product nameAnti-hnRNP C1 + C2 antibody
    See all hnRNP C1 + C2 primary antibodies
  • Description
    Rabbit polyclonal to hnRNP C1 + C2
  • Specificityab61772 detects endogenous levels of total hnRNP C1 + C2 protein.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized non-phosphopeptide derived from human hnRNP C1 + C2 around the phosphorylation site of serine 260 (D-D-SP-A-E).

  • Positive control
    • Extracts from HuvEc cells.



Our Abpromise guarantee covers the use of ab61772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 34 kDa (predicted molecular weight: 34 kDa).
ELISA 1/20000.


  • FunctionBinds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).
  • Sequence similaritiesBelongs to the RRM HNRPC family. RALY subfamily.
    Contains 1 RRM (RNA recognition motif) domain.
  • Post-translational
    Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
    Sumoylated. Sumoylation reduces affinity for mRNA.
  • Cellular localizationNucleus. Component of ribonucleosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • C1 antibody
    • C2 antibody
    • Heterogeneous nuclear ribonucleoprotein C (C1/C2) antibody
    • Heterogeneous nuclear ribonucleoprotein C antibody
    • Heterogeneous nuclear ribonucleoproteins C1/C2 antibody
    • HNRNP antibody
    • hnRNP C1 / hnRNP C2 antibody
    • hnRNP C1/C2 antibody
    • Hnrnpc antibody
    • HNRPC antibody
    • HNRPC_HUMAN antibody
    • MGC104306 antibody
    • MGC105117 antibody
    • MGC117353 antibody
    • MGC131677 antibody
    • Nuclear ribonucleoprotein particle C1 protein antibody
    • Nuclear ribonucleoprotein particle C2 protein antibody
    • SNRPC antibody
    see all

Anti-hnRNP C1 + C2 antibody images

  • All lanes : Anti-hnRNP C1 + C2 antibody (ab61772) at 1/500 dilution

    Lane 1 : extracts from HuvEc cells, treated with EGF (200ng/ml, 5mins) with no peptide
    Lane 2 : extracts from HuvEc cells, treated with EGF (200ng/ml, 5mins) with peptide

    Predicted band size : 34 kDa
    Observed band size : 34 kDa
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

References for Anti-hnRNP C1 + C2 antibody (ab61772)

ab61772 has not yet been referenced specifically in any publications.

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