Overview

  • Product name
    Homatropine methylbromide
  • Description
    Quaternary ammonium muscarinic acetylcholine receptor antagonist
  • Alternative names
    • (N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate bromide
    • HM
    • Homatropine methobromide
    • Homatropine methyl bromide
    • Methylhomatropine
    see all
  • Biological description

    Quaternary ammonium muscarinic acetylcholine receptor antagonist, thus affecting the parasympathetic nervous system.

Properties

  • Chemical name
    [(1R,5S)-8,8-Dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate bromide
  • Molecular weight
    370.28
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H24BrNO3
  • CAS Number
    80-49-9
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Dos Reis DG  et al. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats. Stress 17:362-72 (2014). Read more (PubMed: 24903268) »
  • Deolindo MV  et al. NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats. Eur J Neurosci 38:2374-81 (2013). Read more (PubMed: 23668726) »
  • Bassareo PP  et al. An old drug for use in the prevention of sudden infant unexpected death due to vagal hypertonia. Eur J Pediatr 170:1569-75 (2011). Read more (PubMed: 21814782) »
  • Sim MK & Manjeet S Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens 15:409-21 (1993). Read more (PubMed: 8467326) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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