Overview

  • Product nameAnti-HOMER2 antibody
    See all HOMER2 primary antibodies
  • Description
    Rabbit polyclonal to HOMER2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-343 of Human HOMER2 (NP_004830.2).

  • Positive control
    • Mouse brain lysate, A431 cell lysate, HOMER2 transfected 293T cell line

Properties

Applications

Our Abpromise guarantee covers the use of ab103496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 39 kDa.

Target

  • FunctionPostsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
  • Sequence similaritiesBelongs to the Homer family.
    Contains 1 WH1 domain.
  • DomainThe WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
  • Cellular localizationCytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACPD antibody
    • CPD antibody
    • Cupidin antibody
    • HOME2_HUMAN antibody
    • HOMER 2 antibody
    • HOMER 2A antibody
    • HOMER 2B antibody
    • Homer homolog 2 (Drosophila) antibody
    • Homer homolog 3 antibody
    • Homer neuronal immediate early gene 2 antibody
    • Homer protein homolog 2 antibody
    • Homer-2 antibody
    • Homer2 antibody
    • HOMER2A antibody
    • HOMER2B antibody
    • Vesl 2 antibody
    • Vesl2 antibody
    see all

Anti-HOMER2 antibody images

  • Anti-HOMER2 antibody (ab103496) at 1/500 dilution + Mouse brain lysate at 50 µg

    Predicted band size : 39 kDa
  • Anti-HOMER2 antibody (ab103496) at 1/500 dilution + A431 cell lysate at 50 µg

    Predicted band size : 39 kDa
  • All lanes : Anti-HOMER2 antibody (ab103496) at 1/500 dilution

    Lane 1 : HOMER2 transfected 293T cell line
    Lane 2 : Non transfected 293T cell line

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 39 kDa

References for Anti-HOMER2 antibody (ab103496)

ab103496 has not yet been referenced specifically in any publications.

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