Overview

  • Product nameAnti-HOPX antibody
    See all HOPX primary antibodies
  • Description
    Mouse monoclonal to HOPX
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein: MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VID, corresponding to amino acids 1-74 of Human HOPX

Properties

Applications

Our Abpromise guarantee covers the use of ab57832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAtypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
    • Tissue specificityWidely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
    • Sequence similaritiesContains 1 homeobox DNA-binding domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • FormThere are 2 isoforms produced by alternative splicing.
    • Alternative names
      • CAMEO antibody
      • heart odd homeobox 1 protein antibody
      • HOD antibody
      • Homeodomain-only protein antibody
      • HOP antibody
      • HOP homeobox antibody
      • HOP_HUMAN antibody
      • HOPX antibody
      • LAGY antibody
      • Lung cancer-associated Y protein antibody
      • NECC1 antibody
      • Not expressed in choriocarcinoma clone 1 antibody
      • Not expressed in choriocarcinoma protein 1 antibody
      • OB1 antibody
      • odd homeobox 1 protein antibody
      • Odd homeobox protein 1 antibody
      • OTTHUMP00000158970 antibody
      • SMAP31 antibody
      • TOTO antibody
      see all

    Anti-HOPX antibody images

    • Western blot against tagged recombinant protein immunogen using ab57832 HOPX antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    References for Anti-HOPX antibody (ab57832)

    ab57832 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57832.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"