Human Predicted to work with:
Mouse, Goat, Horse, Cow, Cat, Dog, Pig
Synthetic peptide corresponding to a region within internal sequence amino acids 36 - 85 (RGAVPMSTKR RLEEEQEPLR KQFLSEENMA THFSQLSLHN DHPYCSPPMT) of Human Host cell factor C1 regulator 1 (NP_001002018).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 15 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
FunctionRegulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.
Tissue specificityWidely expressed.
Cellular localizationCytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.