The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesELISA: Use at an assay dependent dilution. A minimum titer of 1/9000 is determined for one of the three peptides.
WB: 1/1000. Predicted molecular weight: 38 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionSequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Tissue specificityStrongly expressed in the adult male and female urogenital tracts.
Involvement in diseaseDefects in HOXD10 are a cause of congenital vertical talus (CVT) [MIM:192950]; also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity.
Sequence similaritiesBelongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Developmental stageExpressed in the developing limb buds.