Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      (C)EAFLNSQKAGKEKD
    • Amino acids
      74 to 87

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-HP1 gamma antibody (ab40827)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CBX 3
    • CBX3
    • CBX3_HUMAN
    • Chromobox homolog 3
    • Chromobox homolog 3 (HP1 gamma homolog, Drosophila)
    • Chromobox protein homolog 3
    • GAMMA
    • HECH
    • Heterochromatin like protein 1
    • Heterochromatin protein 1 homolog gamma
    • Heterochromatin protein HP1 gamma
    • HP1 gamma
    • HP1 gamma homolog
    • HP1Hs gamma
    • Modifier 2 protein
    see all
  • Function
    Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • Sequence similarities
    Contains 2 chromo domains.
  • Post-translational
    modifications
    Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • Cellular localization
    Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
  • Information by UniProt

References

ab45826 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab45826.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up