Overview

  • Product name
  • Description
    Goat polyclonal to HPS3
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity

    Predicted to work with: Human
  • Immunogen

    Synthetic peptide:

    PYLLYCSRKKPLT

    , corresponding to C terminal amino acids 992-1004 of Human HPS3.

  • Positive control
    • A431 cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab19047 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 113 kDa (predicted molecular weight: 113 kDa).
ELISA 1/32000.

Target

  • Relevance
    HPS3 is involved in early stages of melanosome biogenesis and maturation. Defects in HPS3 are the cause of the cocoa (coa) mutant, and of Hermansky-Pudlak syndrome type 3 (HPS3). HPS3 is an autosomal recessive disorder, characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.
  • Cellular localization
    Cytoplasmic
  • Database links
  • Alternative names
    • BLOC2S1 antibody
    • Cocoa antibody
    • DKFZp686F0413 antibody
    • FLJ22704 antibody
    • Hermansky Pudlak syndrome 3 antibody
    • Hermansky Pudlak syndrome 3 protein antibody
    • HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 antibody
    • SUTAL antibody
    see all

Anti-HPS3 antibody images



  • Predicted band size : 113 kDa


    ab19047 (1µg/ml) staining of A431 lysate (35µg protein in RIPA buffer) approx. 113kDa. Primary incubation was 1 hour. Detected by chemiluminescence.

References for Anti-HPS3 antibody (ab19047)

This product has been referenced in:
  • Li K  et al. HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes. J Cell Sci 127:4574-88 (2014). Read more (PubMed: 25189619) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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