Overview

  • Product name
  • Description
    Rabbit polyclonal to HPS6
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig, Monkey
  • Immunogen

    Recombinant fragment, corresponding to a region within internal sequence amino acids 189-459 of Human HPS6 (Uniprot ID: Q86YV9).

  • Positive control
    • 293T, A431, Jurkat, Raji whole cell lysate; Human colon cancer tissue
  • General notes
    Keep as a concentrated solution.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab155194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 83 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function
    May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in HPS6 are the cause of Hermansky-Pudlak syndrome type 6 (HPS6) [MIM:614075]. Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.
  • Cellular localization
    Microsome membrane. Cytoplasm > cytosol. Early endosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BLOC2S3 antibody
    • FLJ22501 antibody
    • Hermansky Pudlak syndrome 6 protein antibody
    • Hermansky-Pudlak syndrome 6 protein antibody
    • HPS6 antibody
    • HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 antibody
    • HPS6_HUMAN antibody
    • MGC20522 antibody
    • Ru antibody
    • Ruby eye protein homolog antibody
    • Ruby-eye protein homolog antibody
    see all

Images

  • Anti-HPS6 antibody (ab155194) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 83 kDa



    7.5% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling HPS6 with ab155194 at 1/500 dilution.

References

ab155194 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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