Overview

  • Product nameAnti-HPSE2 antibody
    See all HPSE2 primary antibodies
  • Description
    Rabbit polyclonal to HPSE2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant protein fragment with a sequence corresponding to a region within amino acids 260 and 552 of Human HPSE2 (NP_068600).

  • Positive control
    • 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji and NIH-3T3 cell lines. Paraffin-embedded lung AdCA.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab97807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionBinds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
  • Tissue specificityWidely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.
  • Involvement in diseaseUrofacial syndrome 1
  • Sequence similaritiesBelongs to the glycosyl hydrolase 79 family.
  • Developmental stageExpressed in the developing forebrain, diencephalon, midbrain, hind brain and spinal cord at Carnagie stage 16 (CS16, 6 weeks of gestation) and CS21 (8 weeks).
  • Cellular localizationSecreted, extracellular space, extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ11684 antibody
    • FLJ44022 antibody
    • heparanase 2 antibody
    • heparanase 3 antibody
    • heparanase-like protein antibody
    • Hpa2 antibody
    • HPR2 antibody
    • HPSE2 antibody
    • HPSE2_HUMAN antibody
    • Inactive heparanase-2 antibody
    • MGC133234 antibody
    • UFS antibody
    see all

Anti-HPSE2 antibody images

  • All lanes : Anti-HPSE2 antibody (ab97807) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa S3 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 67 kDa
  • Anti-HPSE2 antibody (ab97807) at 1/1000 dilution + NIH-3T3 whole cell lysate at 30 µg

    Predicted band size : 67 kDa
  • ab97807, at 1/100, staining paraffin-embedded lung AdCA by Immunohistochemistry.

References for Anti-HPSE2 antibody (ab97807)

ab97807 has not yet been referenced specifically in any publications.

Product Wall

Thank you once again for taking the time to complete our questionnaire and contact us. I am sorry to hear you have had difficulty obtaining satisfactory results from this antibody. The details you have kindly provided will enable us to investig...

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Thank you for contacting us. The immunogen that was used to produce ab97807 shows 100% identity with isoforms 1, 3 and 4 and 99% identity with isoform 2, so it likely recognizes all four isoforms. I hope this information is helpful to you. Plea...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"