Overview

  • Product nameAnti-HPV16 E1+E4 antibody [TVG 403]
    See all HPV16 E1+E4 primary antibodies
  • Description
    Mouse monoclonal [TVG 403] to HPV16 E1+E4
  • Tested applicationsSuitable for: IHC-Fr, ELISA, Flow Cytmore details
  • Species reactivity
    Human papilloma virus.
  • Immunogen

    Fusion protein (Human). Antigen for hybridoma production was expressed as a b-galactosidase fusion protein using the pEX expression system and was consequently cleaved to release the E1/E4 polypeptide.

  • EpitopeE1/E4 protein is aa 36-41 of human papilloma virus type 16.
  • General notes


    This antibody is of value in monitoring the progress of HPV infection from benign lesions to invasive cancer.

Properties

Applications

Our Abpromise guarantee covers the use of ab20190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • RelevanceHPV16 is an ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. HPV16, in comparison to HPV types 6 and 11, is more often associated with malignant genital cancers in humans.
  • Cellular localizationNuclear
  • Alternative names
    • ATP dependent helicase E1 antibody
    • E1 antibody
    • E4 antibody
    • HPV16 E1 antibody
    • HPV16 E4 antibody
    • Human papillomavirus type 16 E1 antibody
    • Human papillomavirus type 16 E4 antibody
    • Replication protein antibody
    • Replication protein E1 antibody
    see all

References for Anti-HPV16 E1+E4 antibody [TVG 403] (ab20190)

This product has been referenced in:
  • Doorbar J  et al. The E1E4 protein of human papillomavirus type 16 associates with a putative RNA helicase through sequences in its C terminus. J Virol 74:10081-95 (2000). Read more (PubMed: 11024137) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"