Anti-HPV16 E6 + HPV18 E6 antibody [C1P5], prediluted (ab51931)

Overview

  • Product nameAnti-HPV16 E6 + HPV18 E6 antibody [C1P5], prediluted
    See all HPV16 E6 + HPV18 E6 primary antibodies
  • Description
    Mouse monoclonal [C1P5] to HPV16 E6 + HPV18 E6, prediluted
  • SpecificityThis antibody is specific for Human Papilloma virus Early Antigen E6, HPV 16 and 18
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human Papillomavirus (HPV)
  • Immunogen

    Human Papilloma virus Early Antigen E6, HPV types 16 und 18, b-galactosidase fusion protein.

  • Positive control
    • HPV-positive vulva carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab51931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.

Target

  • RelevanceHuman Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 1,6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation.
  • Database links
    • Alternative names
      • E6 antibody
      • Human Papilloma Virus antibody
      • Human papillomavirus type 16 E6 antibody
      • Human papillomavirus type 18 E6 antibody
      • Protein E6 antibody
      see all

    Anti-HPV16 E6 + HPV18 E6 antibody [C1P5], prediluted images

    • ab51931 staining HPV 16/18 in combinnation with biotinylated anti-mouse IgG, Streptavidin-AP and Fast Red staining. Retrieval method was antigen unmasking with citrate buffer pH 6 (2 x 5 min microwave oven 600 Watt). ab51931 was used undiluted, secondary AB 1:200, Streptavidin:AP 1:100.

    References for Anti-HPV16 E6 + HPV18 E6 antibody [C1P5], prediluted (ab51931)

    ab51931 has not yet been referenced specifically in any publications.

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    Both current lotswere identical in preparation and the final IgG concentration isapprox. 4.5 µg/ml.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"