The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-HSD11B1 antibody (ab27501)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
11 beta HSD 1
11 beta HSD1
11 beta hydroxysteroid dehydrogenase 1
11-beta hydroxysteroid dehydrogenase, type 1
11-beta-hydroxysteroid dehydrogenase 1
Corticosteroid 11 beta dehydrogenase isozyme 1
Corticosteroid 11-beta-dehydrogenase isozyme 1
Hydroxysteroid (11 beta) dehydrogenase
Hydroxysteroid (11 beta) dehydrogenase 1
short chain dehydrogenase/reductase family 26C, member 1
FunctionCatalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
Tissue specificityWidely expressed. Highest expression in liver.
Involvement in diseaseDefects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.