Overview

  • Product nameAnti-HSD11B2 antibody
    See all HSD11B2 primary antibodies
  • Description
    Rabbit polyclonal to HSD11B2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 284 - 314 of Human HSD11B2

  • Positive control
    • WB: MCF-7 cell line lysates IHC-P: Human skeletal muscle

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab103031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 44 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCatalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
  • Tissue specificityFound in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
  • Involvement in diseaseDefects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
  • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localizationMicrosome. Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • 11 beta HSD2 antibody
    • 11 beta hydroxysteroid dehydrogenase type 2 antibody
    • 11 DH2 antibody
    • 11-beta-HSD2 antibody
    • 11-beta-hydroxysteroid dehydrogenase type 2 antibody
    • 11-DH2 antibody
    • AME antibody
    • AME1 antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 2 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 2 antibody
    • DHI2_HUMAN antibody
    • HSD11B2 antibody
    • HSD11K antibody
    • HSD2 antibody
    • Hydroxysteroid 11 beta dehydrogenase 2 antibody
    • Hydroxysteroid 11 beta dehydrogenase isoenzyme 2 antibody
    • NAD dependent 11 beta hydroxysteroid dehydrogenase antibody
    • NAD-dependent 11-beta-hydroxysteroid dehydrogenase antibody
    • SDR9C3 antibody
    • Short chain dehydrogenase/reductase family 9C, member 3 antibody
    see all

Anti-HSD11B2 antibody images

  • Anti-HSD11B2 antibody (ab103031) at 1/100 dilution + MCF-7 cell line lysates at 35 µg

    Predicted band size : 44 kDa
  • ab103031 at a 1/50 dilution, staining HSD11B2 in formalin fixed and paraffin embedded Human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.

References for Anti-HSD11B2 antibody (ab103031)

ab103031 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab103031.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"