The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/200. Predicted molecular weight: 44 kDa.
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionCatalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Tissue specificityFound in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
Involvement in diseaseDefects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family.
Immunohistochemistry Image of Human Kidney (formalin-fixed, paraffin-embedded) stained with HSD11B2 antibody (ab115696) at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
References for Anti-HSD11B2 antibody (ab115696)
has not yet been referenced specifically in any publications.
Publishing research using ab115696? Please let us know so that we can cite the reference in this datasheet.
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