• Product name
    Anti-HSD17B1 antibody [EP1682Y]
    See all HSD17B1 primary antibodies
  • Description
    Rabbit monoclonal [EP1682Y] to HSD17B1
  • Tested applications
    Suitable for: WB, ICC/IF, Flow Cyt, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human HSD17B1 (C terminal). The exact sequence is proprietary.

  • Positive control
    • WB: Human placenta lysate. IHC-P: Human placenta tissue.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


Associated products


Our Abpromise guarantee covers the use of ab51045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
ICC/IF 1/100 - 1/250.
Flow Cyt Use 1µg for 106 cells.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

IP 1/100.
IHC-P 1/100 - 1/250.


  • Function
    Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
  • Pathway
    Steroid biosynthesis; estrogen biosynthesis.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • 17 beta HSD 1 antibody
    • 17 beta hydroxysteroid dehydrogenase type 1 antibody
    • 17-beta-HSD 1 antibody
    • 17-beta-hydroxysteroid dehydrogenase type 1 antibody
    • 20 alpha-hydroxysteroid dehydrogenase antibody
    • 20-alpha-HSD antibody
    • DHB1_HUMAN antibody
    • E17KSR antibody
    • E2DH antibody
    • EDH17B1 antibody
    • EDH17B2 antibody
    • EDHB17 antibody
    • Estradiol 17 beta dehydrogenase 1 antibody
    • Estradiol 17-beta-dehydrogenase 1 antibody
    • HSD17 antibody
    • HSD17B1 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 1 antibody
    • MGC13814 antibody
    • Placental 17 beta hydroxysteroid dehydrogenase antibody
    • Placental 17-beta-hydroxysteroid dehydrogenase antibody
    • SDR28C1 antibody
    • Short chain dehydrogenase/reductase family 28CE,member 1 antibody
    see all

Anti-HSD17B1 antibody [EP1682Y] images

  • Anti-HSD17B1 antibody [EP1682Y] (ab51045) at 1/100000 dilution + Human placenta lysate at 10 µg

    Goat anti-Rabbit HRP labeled. at 1/2000 dilution

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
  • Ab51045 (1/100 dilution) staining human HSD17B1 in paraffin embedded human placenta tissue by Immunohistochemistry.
  • Overlay histogram showing JEG3 cells stained with ab51045 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab51045, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1µg/1x106 cells ) used under the same conditions. Acquisition of >5,000 events was performed.

References for Anti-HSD17B1 antibody [EP1682Y] (ab51045)

This product has been referenced in:
  • Rižner TL Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer. Mol Cell Endocrinol 381:124-39 (2013). Human . Read more (PubMed: 23911898) »
  • Zhang CY  et al. The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells. PLoS One 7:e29835 (2012). WB ; Human . Read more (PubMed: 22253796) »

See all 5 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab51045.
Please use the links above to contact us or submit feedback about this product.


Sign up