Overview

  • Product name
  • Description
    Mouse polyclonal to Hsd17b11
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Human, Chimpanzee, Rhesus monkey, Common marmoset, Orangutan
  • Immunogen

    Full length protein corresponding to amino acids 1-300 of Human Hsd17b11 (AAH36001.1).

  • Positive control
    • Hsd17b11 transfected 293T cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Purity
    Whole antiserum
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab167686 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 33 kDa.

Target

  • Function
    Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
  • Tissue specificity
    Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • 17 beta HSD 11 antibody
    • 17 beta HSD XI antibody
    • 17 BETA HSD11 antibody
    • 17 BETA HSDXI antibody
    • 17 beta hydroxysteroid dehydrogenase 11 antibody
    • 17 beta hydroxysteroid dehydrogenase type XI antibody
    • 17 beta hydroxysteroid dehydrogenase XI antibody
    • 17-beta-HSD 11 antibody
    • 17-beta-HSD XI antibody
    • 17-beta-hydroxysteroid dehydrogenase 11 antibody
    • 17-beta-hydroxysteroid dehydrogenase XI antibody
    • 17betaHSD11 antibody
    • 17betaHSDXI antibody
    • 17bHSD11 antibody
    • CTCL associated antigen HD CL 03 antibody
    • CTCL tumor antigen HD CL 03 antibody
    • CTCL-associated antigen HD-CL-03 antibody
    • Cutaneous T cell lymphoma associated antigen HD CL 03 antibody
    • Cutaneous T-cell lymphoma-associated antigen HD-CL-03 antibody
    • Dehydrogenase/reductase SDR family member 8 antibody
    • DHB11_HUMAN antibody
    • DHRS8 antibody
    • Estradiol 17 beta dehydrogenase 11 antibody
    • Estradiol 17-beta-dehydrogenase 11 antibody
    • Hsd17b11 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 11 antibody
    • PAN1B antibody
    • Retinal short chain dehydrogenase/reductase 2 antibody
    • Retinal short-chain dehydrogenase/reductase 2 antibody
    • RETSDR2 antibody
    • SDR16C2 antibody
    • SDR2 antibody
    • Short chain dehydrogenase/reductase family 16C member 2 antibody
    • T cell lymphoma associated antigen HD CL 03 antibody
    see all

Images

  • All lanes : Anti-Hsd17b11 antibody (ab167686) at 1/500 dilution

    Lane 1 : Hsd17b11 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG at 1/5000 dilution

    Predicted band size: 33 kDa

References

ab167686 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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