Overview

  • Product nameAnti-HSD17B12 antibody
    See all HSD17B12 primary antibodies
  • Description
    Mouse polyclonal to HSD17B12
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    MESALPAAGF LYWVGAGTVA YLALRISYSL FTALRVWGVG NEAGVGPGLG , corresponding to amino acids 1-98 of Human HSD17B12

  • Positive control
    • HSD17B12-transfected mammalian cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab68333 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

Target

  • FunctionCatalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
  • Tissue specificityExpressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.
  • PathwaySteroid biosynthesis; estrogen biosynthesis.
    Lipid metabolism; fatty acid biosynthesis.
  • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • DomainThe di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 12,3-ketoacyl-CoA reductase,short chain antibody
    • 17 beta HSD 12 antibody
    • 17 beta hydroxysteroid dehydrogenase 12 antibody
    • 17-@beta-HSD XII antibody
    • 17-@beta-hydroxysteroid dehydrogenase XII antibody
    • 17-beta-HSD 12 antibody
    • 17-beta-hydroxysteroid dehydrogenase 12 antibody
    • 17beta HSD type 12 antibody
    • 3 ketoacyl CoA reductase antibody
    • 3-ketoacyl-CoA reductase antibody
    • DHB12_HUMAN antibody
    • Estradiol 17 beta dehydrogenase 12 antibody
    • Estradiol 17-beta-dehydrogenase 12 antibody
    • HSD17B12 antibody
    • Hydroxysteroid (17-beta) dehydrogenase 12 antibody
    • KAR antibody
    • KIK-I antibody
    • Kik1 antibody
    • SDR12C1 antibody
    • Short chain dehydrogenase/reductase family 12C member 1 antibody
    • Steroid dehydrogenase homolog antibody
    see all

Anti-HSD17B12 antibody images

  • All lanes : Anti-HSD17B12 antibody (ab68333) at 1/500 dilution

    Lane 1 : HSD17B12 (aa 1-98) transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugated at 1/2500 dilution

    Predicted band size : 34 kDa

References for Anti-HSD17B12 antibody (ab68333)

ab68333 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"