Overview

  • Product nameAnti-HSD17B3 antibody
    See all HSD17B3 primary antibodies
  • Description
    Rabbit polyclonal to HSD17B3
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a sequence between internal sequence amino acids 96-126 of Human HSD17B3.

  • Positive control
    • K562 cell line lysates and Human testis tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab102771 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 35 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionFavors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
  • Tissue specificityTestis.
  • PathwayHormone biosynthesis; testosterone biosynthesis.
  • Involvement in diseaseDefects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH) [MIM:264300]. These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place.
  • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • 17 @beta HSD III antibody
    • 17 beta HSD 3 antibody
    • 17-@beta hydroxysteroid dehydrogenase III antibody
    • 17-beta-HSD 3 antibody
    • 17-beta-hydroxysteroid dehydrogenase type 3 antibody
    • DHB3_HUMAN antibody
    • EC 1.1.1.64 antibody
    • EDH17B3 antibody
    • Estradiol 17 beta dehydrogenase antibody
    • Estradiol 17 beta dehydrogenase 3 antibody
    • HSD17B3 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 3 antibody
    • OTTHUMP00000021718 antibody
    • SDR12C2 antibody
    • Short chain dehydrogenase/reductase family 12C member 2 antibody
    • Testicular 17 @beta hydroxysteroid dehydrogenase III antibody
    • Testicular 17 beta hydroxysteroid dehydrogenase antibody
    • Testicular 17-beta-hydroxysteroid dehydrogenase antibody
    • Testosterone 17 beta dehydrogenase 3 antibody
    • Testosterone 17-beta-dehydrogenase 3 antibody
    see all

Anti-HSD17B3 antibody images

  • Anti-HSD17B3 antibody (ab102771) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 35 kDa
  • ab102771 at 1/50 dilution staining HSD17B3 in Human testis tissue by Immunohistochemistry. Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

References for Anti-HSD17B3 antibody (ab102771)

ab102771 has not yet been referenced specifically in any publications.

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