Overview

  • Product name
  • Description
    Rabbit polyclonal to HSD17B3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 122 and 297 of Human HSD17B3 (UniProt ID: P37058).

  • Positive control
    • WB: Raji whole cell lysate IHC-P: Hepatoma

Properties

Applications

Our Abpromise guarantee covers the use of ab126228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function
    Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
  • Tissue specificity
    Testis.
  • Pathway
    Hormone biosynthesis; testosterone biosynthesis.
  • Involvement in disease
    Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH) [MIM:264300]. These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • 17 @beta HSD III antibody
    • 17 beta HSD 3 antibody
    • 17-@beta hydroxysteroid dehydrogenase III antibody
    • 17-beta-HSD 3 antibody
    • 17-beta-hydroxysteroid dehydrogenase type 3 antibody
    • DHB3_HUMAN antibody
    • EC 1.1.1.64 antibody
    • EDH17B3 antibody
    • Estradiol 17 beta dehydrogenase antibody
    • Estradiol 17 beta dehydrogenase 3 antibody
    • HSD17B3 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 3 antibody
    • OTTHUMP00000021718 antibody
    • SDR12C2 antibody
    • Short chain dehydrogenase/reductase family 12C member 2 antibody
    • Testicular 17 @beta hydroxysteroid dehydrogenase III antibody
    • Testicular 17 beta hydroxysteroid dehydrogenase antibody
    • Testicular 17-beta-hydroxysteroid dehydrogenase antibody
    • Testosterone 17 beta dehydrogenase 3 antibody
    • Testosterone 17-beta-dehydrogenase 3 antibody
    see all

Images

  • Anti-HSD17B3 antibody (ab126228) at 1/500 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 35 kDa
  • ab126228, at a 1/500 dilution, staining HSD17B3 in paraffin embedded Hepatoma by Immunohistochemistry.

References

ab126228 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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