Overview

  • Product nameAnti-HSD17B3 antibody
    See all HSD17B3 primary antibodies
  • Description
    Mouse polyclonal to HSD17B3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human HSD17B3 protein (NP_000188.1)

  • Positive control
    • HSD17B3 transfected 293T cell lysate.

Applications

Our Abpromise guarantee covers the use of ab70089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 30 kDa (predicted molecular weight: 35 kDa).

Target

  • FunctionFavors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
  • Tissue specificityTestis.
  • PathwayHormone biosynthesis; testosterone biosynthesis.
  • Involvement in diseaseDefects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH) [MIM:264300]. These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place.
  • Sequence similaritiesBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • 17 @beta HSD III antibody
    • 17 beta HSD 3 antibody
    • 17-@beta hydroxysteroid dehydrogenase III antibody
    • 17-beta-HSD 3 antibody
    • 17-beta-hydroxysteroid dehydrogenase type 3 antibody
    • DHB3_HUMAN antibody
    • EC 1.1.1.64 antibody
    • EDH17B3 antibody
    • Estradiol 17 beta dehydrogenase antibody
    • Estradiol 17 beta dehydrogenase 3 antibody
    • HSD17B3 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 3 antibody
    • OTTHUMP00000021718 antibody
    • SDR12C2 antibody
    • Short chain dehydrogenase/reductase family 12C member 2 antibody
    • Testicular 17 @beta hydroxysteroid dehydrogenase III antibody
    • Testicular 17 beta hydroxysteroid dehydrogenase antibody
    • Testicular 17-beta-hydroxysteroid dehydrogenase antibody
    • Testosterone 17 beta dehydrogenase 3 antibody
    • Testosterone 17-beta-dehydrogenase 3 antibody
    see all

Anti-HSD17B3 antibody images

  • All lanes : Anti-HSD17B3 antibody (ab70089) at 1/500 dilution

    Lane 1 : HSD17B3 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 35 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

References for Anti-HSD17B3 antibody (ab70089)

ab70089 has not yet been referenced specifically in any publications.

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